DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4598 and Eci2

DIOPT Version :9

Sequence 1:	NP_001260304.1	Gene:	CG4598 / 34315	FlyBaseID:	FBgn0032160	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001103801.1	Gene:	Eci2 / 23986	MGIID:	1346064	Length:	391	Species:	Mus musculus

Alignment Length:	272	Identity:	54/272 - (19%)
Similarity:	92/272 - (33%)	Gaps:	94/272 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VNDKTGIATLTMNRP-PVNGLNLELLQDLKSSIDEIESNKSRGLILTSSSSTIFSAGLDILEMYK 93
            |..:.||..:|.||| ..|.::.::.:|:..::....::.:...:.|.:.. .:.:|.|:.....
Mouse   142 VTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGD-YYCSGNDLTNFTS 205

  Fly    94 PD--------------KDRIRAFWTQLQDTWLALYGSSVPTAAAINGHSPAGGCLLATSCEYRVM 144
            ..              :|.:.:|           .....|..|.:||  ||
Mouse   206 ATGGIEEAASNGAVLLRDFVNSF-----------IDFPKPLVAVVNG--PA-------------- 243

  Fly   145 VPNFTIGLNETQLGIVAPQWFMASFLS----------------------VLPQRI----AERALN 183
                 :|::.|.||:     |.|.|.|                      ..|:.:    |...|.
Mouse   244 -----VGISVTLLGL-----FDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLL 298

  Fly   184 QGRMFTTEEALKVGLIDETANNKEEAIEKCV-AFIGTFAKVNPLARSLTKQQFRAADLQQLQNGR 247
            .|:..|..||...||:.|..  .|...|..| ..:.|:||:.|.|..::|:..           |
Mouse   299 FGKKLTAREAWAQGLVTEVF--PESTFETEVWTRLKTYAKLPPNAMRISKELI-----------R 350

  Fly   248 KEDLEKFLFFVN 259
            |.:.|| |:.||
Mouse   351 KNEKEK-LYAVN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4598	NP_001260304.1	crotonase-like	27..217	CDD:119339	41/228 (18%)
Eci2	NP_001103801.1	ACBP	38..113	CDD:279259
		Acyl-CoA binding. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..136
		crotonase-like	139..389	CDD:304874	54/272 (20%)
		ECH-like	149..319		35/209 (17%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	196..200		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	389..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810