DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4598 and Cdyl

DIOPT Version :9

Sequence 1:	NP_001260304.1	Gene:	CG4598 / 34315	FlyBaseID:	FBgn0032160	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	298	Identity:	59/298 - (19%)
Similarity:	112/298 - (37%)	Gaps:	69/298 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SNRMMSTATKLTTVEVNDKTGIA--TLTMNRPPVNGLNLELLQDLKSSIDEIESNKSRGLILTSS 77
            |.|...:|.:...:.|..:.|..  .|:......|.||.|::::::|::....::.|: |:|.|:
Mouse   326 SVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDSK-LVLLSA 389

  Fly    78 SSTIFSAGLDILEMYKPDKDRIRAFWTQLQDTWLALYGSSV----PTAAAINGHSPAGGCLLATS 138
            ..::|..|||.:...:...|..:...|::.|.......:.:    |...|:||.:...|..:...
Mouse   390 VGSVFCCGLDFIYFIRRLTDDRKRESTKMADAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPL 454

  Fly   139 CEYRVMVPNFTIGLNETQLGIVAPQWFMASFLS-----------VLPQRIAERALNQ----GRMF 188
            |:        .:..||       ..||...:.:           :.|:.:...:.|:    ||..
Mouse   455 CD--------VVWANE-------KAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLFSGRKL 504

  Fly   189 TTEEALKVGLIDETANNKEEAIEKCVAFIGTF-----------AKVNPLARSLTKQQFRA---AD 239
            |.:||...||:.:            |.:.|||           |..||:....:|...|.   .:
Mouse   505 TAQEACGKGLVSQ------------VFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKME 557

  Fly   240 LQQLQNGRKEDLEKFLFFVNQPAVQKGLGIYLEGLKKK 277
            |:|......|.|:|..      ...:|:...|:.|::|
Mouse   558 LEQANERECEVLKKIW------GSAQGMDSMLKYLQRK 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4598	NP_001260304.1	crotonase-like	27..217	CDD:119339	39/210 (19%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223
		crotonase-like	339..535	CDD:119339	42/223 (19%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		52/265 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810