DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4598 and ECI2

DIOPT Version :9

Sequence 1:	NP_001260304.1	Gene:	CG4598 / 34315	FlyBaseID:	FBgn0032160	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_996667.2	Gene:	ECI2 / 10455	HGNCID:	14601	Length:	394	Species:	Homo sapiens

Alignment Length:	275	Identity:	56/275 - (20%)
Similarity:	101/275 - (36%)	Gaps:	76/275 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GSNRMMSTATKLTTVEVNDKTGIATLTMNRP-PVNGLNLELLQDLKSSIDEIESNKSRGLILTSS 77
            |::|   .:|...|:.|..:.||..:..||| ..|.:|.|:..::..::.....:.|...:||.:
Human   131 GTDR---KSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGN 192

  Fly    78 SSTIFSAGLDIL-----------EMYKPDKDRIRAFWTQLQDTWLALYGSSV----PTAAAINGH 127
            .. .:|:|.|:.           |..|.:...:|.|           .|..:    |..|.:||
Human   193 GD-YYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREF-----------VGCFIDFPKPLIAVVNG- 244

  Fly   128 SPAGGCLLATSCEYRVMVPNFTIGLNETQLGIV--------------------APQWFMA-SFLS 171
             ||                   :|::.|.||:.                    :|:...: :|..
Human   245 -PA-------------------VGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPK 289

  Fly   172 VLPQRIAERALNQGRMFTTEEALKVGLIDETANNKEEAIEKCV-AFIGTFAKVNPLARSLTKQQF 235
            ::....|...|..|:..|..||...||:.|..  .:...:|.| ..:..|||:.|.|..::|:..
Human   290 IMSPAKATEMLIFGKKLTAGEACAQGLVTEVF--PDSTFQKEVWTRLKAFAKLPPNALRISKEVI 352

  Fly   236 RAADLQQLQNGRKED 250
            |..:.::|.....|:
Human   353 RKREREKLHAVNAEE 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4598	NP_001260304.1	crotonase-like	27..217	CDD:119339	44/227 (19%)
ECI2	NP_996667.2	ACBP	40..113	CDD:279259
		Acyl-CoA binding. /evidence=ECO:0000250	66..70
		crotonase-like	142..335	CDD:119339	43/227 (19%)
		ECH-like	151..322		38/205 (19%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	198..202		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	392..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810