Protein Alignment Srp54 and SRSF11

DIOPT Version :9

• Sequence 1: NP_477347.1
• Gene: Srp54 / 34312
• FlyBaseID: FBgn0024285
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001381331.1
• Gene: SRSF11 / 9295
• HGNCID: 10782
• Length: 494
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 181/568 - (31%)
• Similarity: 251/568 - (44%)
• Gaps: 160/568 - (28%)

  Fly     3 GGNTPRVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYP----------TIRDVSCPVQSRICYV 57
            ||....||||||::|.|:.:||:||||.:|||:|:||:|          .:.|...||.||:|:|
Human    28 GGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPEKLESSKNLLLCDSPLPVSSRVCFV 92

  Fly    58 KYTDTTSVPVAQHLTNTVFIDRALIVIPVL--AIPEEYRALEMLKNGTIVPGLQKPDSKLP-PEV 119
            |:.|..|..||||||||||:||||||:|..  .||:|.:||.:|.....|.||......|| |..
Human    93 KFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNP 157

  Fly   120 INRIEGQLPQQVI--KTYDPKLVEFNLPEYPALPSFYDARKIEEIRRTIIVCDVKNEWRLDDLME 182
            :.:| |.:|...:  .|.||.|....||..........|.::.::..|:
Human   158 LTQI-GAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTV---------------- 205

  Fly   183 CFQRAGEVKYARWAEKDNKTYCMIEFCEQTSIIHALRMQGQEFKGGHLSVYHSTYSITKPEAKSN 247
                            |.|                              :.|....:..|..||:
Human   206 ----------------DPK------------------------------LNHVAAGLVSPSLKSD 224

  Fly   248 EAAQAEIEEAMTIVKEAQSMISAAIDPVIGMLAKDKRRRSRSRSRSRDRRTSRSRSHRSTSRRRS 312
            .::: ||||||..|:||||:|||||:|   ...::|||.||||||||.|||.
Human   225 TSSK-EIEEAMKRVREAQSLISAAIEP---DKKEEKRRHSRSRSRSRRRRTP------------- 272

  Fly   313 RRSGSRERRSVSRSRRSRSRGKHSSRSRSKRSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGKRSR 377
              |.||.|||.||||| ||..|..||.|||..|.|...|..|.|||||       :|::|.|:..
Human   273 --SSSRHRRSRSRSRR-RSHSKSRSRRRSKSPRRRRSHSRERGRRSRS-------TSKTRDKKKE 327

  Fly   378 SRHRRSTSRSRS-SRSHGTGGGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSRSKRSSPSPPPAT 441
            .:.::   ||:: .:|:.|     ....||.||||.::..||...|.:.|||..::.|.||.|..
Human   328 DKEKK---RSKTPPKSYST-----ARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRR 384

  Fly   442 GSKSR-----SSRSKDPVIVSAKSSRRRDRSRTPETRKLKSISEDTEVKSSRS------------ 489
            ..|.:     ..||:|.   ..:|:.::.:|:..|..:.:....|.:||.:|.
Human   385 HKKEKKKDKDKERSRDE---RERSTSKKKKSKDKEKDRERKSESDKDVKVTRDYDEEEQGYDSEK 446

  Fly   490 ---------SADSKSRKSVSVEK-----------------SDNMDISN 511
                     ...|...|..||||                 .::||:|:
Human   447 EKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:240705	47/85 (55%)
		RRM2_SREK1	160..242	CDD:240706	4/81 (5%)
SRSF11	NP_001381331.1	RRM	34..118	CDD:214636	45/83 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147823
Domainoid	1	1.000	69	1.000	Domainoid score	I9686
eggNOG	1	0.900	-	-		E1_KOG4676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4132
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45943
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003613
OrthoInspector	1	1.000	-	-		oto88668
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32343
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.950