DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srp54 and Srek1

DIOPT Version :9

Sequence 1:	NP_477347.1	Gene:	Srp54 / 34312	FlyBaseID:	FBgn0024285	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_036013913.1	Gene:	Srek1 / 218543	MGIID:	2145245	Length:	631	Species:	Mus musculus

Alignment Length:	569	Identity:	199/569 - (34%)
Similarity:	278/569 - (48%)	Gaps:	90/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYPTIRDVSCPVQSRICYVKYTDTTSVPVAQHLTN 73
            ||||||::...|.:||:|||..:|:|||:||||. .:......|::||:|:.|.:||.|||||||
Mouse    20 VIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPP-DNTPLAFSSKVCYIKFRDPSSVGVAQHLTN 83

  Fly    74 TVFIDRALIVIPVL--AIPEEYRALEMLKNG----TIVPG---LQKPDSKLPPEVINRIE----- 124
            ||||||||||:|..  .||||.:||.:|...    ::|||   |..|.|. |...::.:.
Mouse    84 TVFIDRALIVVPCAEGKIPEEAKALSLLAPAPTMTSLVPGAGLLPIPTSS-PLTAVSSLGVSLSS 147

  Fly   125 -GQLPQQVIKTYDPKLVEFNLPEYPALPSFYDARKIEEIRRTIIVCDVKNE-WRLDDLMECFQRA 187
             |.:|...:   ||.:........|.|....|..||:|||||:.|.::.:: ...|.|:|.|::.
Mouse   148 LGAIPAAAL---DPNITTLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQV 209

  Fly   188 GEVKYARWA--EKDNKTYCMIEFCEQTSIIHALRMQGQEFKGGHLSVYHSTYSITKPEAKSNEAA 250
            ||||:.|.|  |.....:..:||.:|.|:..||...|..|....|.:.||..:|.||...:.:||
Mouse   210 GEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAA 274

  Fly   251 QAEIEEAMTIVKEAQSMISAAIDPVIGMLAKDKRRRSRSRSRSRDRRTSRSRS--------HRST 307
            ..|:||.|..|:||||.|||||:|..|...:.|..||||.:||:.|.:|:|.|        |||.
Mouse   275 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSR 339

  Fly   308 SRRRSRRSGSRERRSVS-RSRRSRSRGKHSSRSRSKRSRSRHRRSSSRSR-------------RS 358
            |..|||......|||.| ..:||:||.:..|||   |||||.:|..:|.:             |.
Mouse   340 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS---RSRSRDKRKDTREKVKERVKEKEREKERE 401

  Fly   359 RSRG-------GKHSRSSRSRGK-------------------RSRSRHRRSTSRSRSSRSHGTGG 397
            |.:.       ||:....|.:.|                   |.:.|.:.:..:.:..:...|..
Mouse   402 REKDREKDKERGKNKDKDREKEKDHEKERDKEKEKEQDKDKEREKDRSKETDEKRKKEKKSRTPP 466

  Fly   398 GGSGNGKRSRSRERSKKSHRSEKHSSRSPRSR---SKRSSPSPPPATGSKSRSSRSKDPVIVSAK 459
            ......:||||..|.::..|| :.||||||:.   .::||.||.|...:|....|.|:...:
Mouse   467 RSYNASRRSRSTSRERRRRRS-RSSSRSPRTSKTVKRKSSRSPSPRGRNKKEKKREKERDHI--- 527

  Fly   460 SSRRRDRSRTPETRKL--------KSISEDTEVKSSRSSADSKSRKSVS 500
             |.||:|.|:..|:|.        |.....|.||.|||:......|..|
Mouse   528 -SDRRERERSTSTKKSSGDRDGKEKVEKSTTPVKVSRSARACVKEKRCS 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:240705	44/75 (59%)
Srp54	NP_477347.1	RRM2_SREK1	160..242	CDD:240706	29/84 (35%)
Srek1	XP_036013913.1	RRM1_SREK1	20..99	CDD:409941	45/79 (57%)
Srek1	XP_036013913.1	RRM2_SREK1	181..266	CDD:409705	29/84 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4676
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4122
Isobase	1	0.950	-	0	Normalized mean entropy	S2739
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003613
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105433
Panther	1	1.100	-	-	LDO	PTHR32343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5511
SonicParanoid	1	1.000	-	-		X2488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800