Protein Alignment Srp54 and SREK1

DIOPT Version :9

• Sequence 1: NP_477347.1
• Gene: Srp54 / 34312
• FlyBaseID: FBgn0024285
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001070667.1
• Gene: SREK1 / 140890
• HGNCID: 17882
• Length: 624
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 201/592 - (33%)
• Similarity: 278/592 - (46%)
• Gaps: 102/592 - (17%)

  Fly     4 GNTP-RVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYPTIRDVSCPVQSRICYVKYTDTTSVPV 67
            |.|| .||||||::...|.:||:|||..:|:|||:||||. .:......|::||||:.|.:||.|
Human    14 GLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPP-DNAPLAFSSKVCYVKFRDPSSVGV 77

  Fly    68 AQHLTNTVFIDRALIVIPVL--AIPEEYRALEMLKNGTIVPGLQKPDSKLPPEVINRIE------ 124
            ||||||||||||||||:|..  .||||.:||.:|.....:..|......||....|.:.
Human    78 AQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSLMPGAGLLPIPTPNPLTTLGVSL 142

  Fly   125 ---GQLPQQVIKTYDPKLVEFNLPEYPALPSFYDARKIEEIRRTIIVCDVKNE-WRLDDLMECFQ 185
               |.:|...:   ||.:........|.|....|..||:|||||:.|.::.:: ...|.|:|.|:
Human   143 SSLGAIPAAAL---DPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFK 204

  Fly   186 RAGEVKYARWA--EKDNKTYCMIEFCEQTSIIHALRMQGQEFKGGHLSVYHSTYSITKPEAKSNE 248
            :.||||:.|.|  |.....:..:||.:|.|:..||...|..|....|.:.||..:|.||...:.:
Human   205 QVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQ 269

  Fly   249 AAQAEIEEAMTIVKEAQSMISAAIDPVIGMLAKDKRRRSRSRSRSRDRRTSRSRS--------HR 305
            ||..|:||.|..|:||||.|||||:|..|...:.|..||||.:||:.|.:|:|.|        ||
Human   270 AAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHR 334

  Fly   306 STSRRRSR---------------RSGSRERRSVSRSR---------------------------- 327
            |.|..|||               ||.|||||. ||||
Human   335 SRSHNRSRSRQKDRRRSKSPHKKRSKSRERRK-SRSRSHSRDKRKDTREKIKEKERVKEKDREKE 398

  Fly   328 --RSRSRGKHSSRSRSK---RSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGK---------RSRS 378
              |.:.|.|...|.::|   :.|.:.|.......|.|.|..:|.: .|.:.|         |.:.
Human   399 REREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK-DRDKEKEKEQDKEKEREKD 462

  Fly   379 RHRRSTSRSRSSRSHGTGGGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSR---SKRSSPSPPPA 440
            |.:....:.:..:...|........:||||..|.::..|| :.||||||:.   .::||.||.|.
Human   463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS-RSSSRSPRTSKTIKRKSSRSPSPR 526

  Fly   441 TGSKSRSSRSKDPVIVSAKSSRRRDRSRTPETRKLKSISEDTEVKSSRSSADSKSRK-------S 498
            :.:|....|.|:...:    |.||:|.|:...|| .|...|.:.|..::|...|.::       |
Human   527 SRNKKDKKREKERDHI----SERRERERSTSMRK-SSNDRDGKEKLEKNSTSLKEKEHNKEPDSS 586

  Fly   499 VSVEKSD 505
            ||.|..|
Human   587 VSKEVDD 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:240705	45/75 (60%)
		RRM2_SREK1	160..242	CDD:240706	29/84 (35%)
SREK1	NP_001070667.1	RRM1_SREK1	20..99	CDD:240963	46/79 (58%)
		RRM2_SREK1	178..263	CDD:240706	29/84 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4676
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003613
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105433
Panther	1	1.100	-	-	LDO	PTHR32343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5511
SonicParanoid	1	1.000	-	-		X2488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730