DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srp54 and srek1

DIOPT Version :9

Sequence 1:	NP_477347.1	Gene:	Srp54 / 34312	FlyBaseID:	FBgn0024285	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_002934235.1	Gene:	srek1 / 100329115	XenbaseID:	XB-GENE-491758	Length:	566	Species:	Xenopus tropicalis

Alignment Length:	572	Identity:	204/572 - (35%)
Similarity:	291/572 - (50%)	Gaps:	107/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGGNTPRVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYPTIRDVSCPVQSRICYVKYTDTTSV 65
            |:.|.| .||||||::...|.|||:|||..:|.|||:||||. .:......|::|||||.:.:||
Frog     1 MSPGQT-TVIQVTNLSAAVTSDQMRTLFSFLGDIEELRLYPP-DNAPLAFSSKVCYVKYREPSSV 63

  Fly    66 PVAQHLTNTVFIDRALIVIPVL--AIPEEYRALEML----KNGTIVPG---LQKP-DSKLPP--- 117
            .|||||||||||||||||:|..  .||||.:||.:|    ...:::||   |..| .:..||
Frog    64 GVAQHLTNTVFIDRALIVVPCAEGKIPEETKALSLLAPAPSLSSLLPGAGLLPIPAPTPTPPIAS 128

  Fly   118 ---EVINRIEGQLP-----------------QQVIKTYDPKLVEF--------NLPEYPALPSFY 154
               .|:.|.:.::|                 :.||.|..|.|...        :||: |.|....
Frog   129 SLASVLRREKVEVPLLSVPLTSLGVNLPTPLEPVITTLAPVLPALTPAIPAVADLPQ-PPLMGNV 192

  Fly   155 DARKIEEIRRTIIVCDVKNE-WRLDDLMECFQRAGEVKYARWA--EKDNKTYCMIEFCEQTSIIH 216
            |..|::||||||.|.::.:: ...:.|:|.|::.|:|::.|.|  |.....:..:||.:|.|:..
Frog   193 DPTKVDEIRRTIYVGNLNSQTTTAEQLLEFFKQVGDVRFVRMAGDETQPTRFAFVEFSDQNSVTR 257

  Fly   217 ALRMQGQEFKGGHLSVYHSTYSITKPEAKSNEAAQAEIEEAMTIVKEAQSMISAAIDPVIGM-LA 280
            ||...|..|....|.:.||..:|.||...:.:||..|:||.|..|:||||.|||||:|..|. :.
Frog   258 ALTFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPETGKPVE 322

  Fly   281 KDKRRRSRSRSRSRDRRTSRSRSHRSTSRRRSRRSGSRERRSVSRSRRSRSRGKHSSRSRS---- 341
            |.|:..|::|||||.:  ||||..||.|:.||.             .|:|||.:|..|.||
Frog   323 KIKQEHSKTRSRSRSK--SRSRRKRSRSKNRSH-------------SRNRSRSRHKERRRSKSPH 372

  Fly   342 -KRSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGKR---------SRSRHRRSTSRSRSSRSHGTG 396
             |||:|:.||.|  ..|||||..|..:..:|:|:.         .:.:.:||.|.|:||.|.
Frog   373 KKRSKSKDRRKS--KSRSRSRDRKKEKEYKSKGREKEKQKDKYDKKRKEKRSRSPSKSSSSI--- 432

  Fly   397 GGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSRS--KRSSPSPPPATGSKSRSSRSKDPVIVSAK 459
                   :||:|..|.|:..|| :..|:|||:..  ||||.||.|.  ||:|..:         |
Frog   433 -------RRSQSASREKRKRRS-RSLSKSPRTSKTLKRSSRSPSPR--SKNRKEK---------K 478

  Fly   460 SSRRRDRSRTPETRKLKSISEDTEVKSSRSSAD----SKSRKSVSVEKSDNM 507
            ..:.||.:.....|:.....:.::|:..:.:||    ..|.|..|.::.:||
Frog   479 KGKERDHNGNRHEREHSGSQKRSKVQERKEAADHYNTKLSEKHHSKDERNNM 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:240705	46/75 (61%)
Srp54	NP_477347.1	RRM2_SREK1	160..242	CDD:240706	27/84 (32%)
srek1	XP_002934235.1	RRM1_SREK1	8..87	CDD:240963	47/79 (59%)
srek1	XP_002934235.1	RRM2_SREK1	198..283	CDD:240706	27/84 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1342709at2759
OrthoFinder	1	1.000	-	-		FOG0003613
OrthoInspector	1	1.000	-	-		otm47678
Panther	1	1.100	-	-	LDO	PTHR32343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5511
SonicParanoid	1	1.000	-	-		X2488
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100