Protein Alignment Srp54 and srek1

DIOPT Version :10

• Sequence 1: NP_477347.1
• Gene: Srp54 / 34312
• FlyBaseID: FBgn0024285
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: XP_002934235.1
• Gene: srek1 / 100329115
• XenbaseID: XB-GENE-491758
• Length: 566
• Species: Xenopus tropicalis
• Alignment Length: 572
• Identity: 204/572 - (35%)
• Similarity: 291/572 - (50%)
• Gaps: 107/572 - (18%)

  Fly     1 MAGGNTPRVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYPTIRDVSCPVQSRICYVKYTDTTSV 65
            |:.|.| .||||||::...|.|||:|||..:|.|||:||||. .:......|::|||||.:.:||
 Frog     1 MSPGQT-TVIQVTNLSAAVTSDQMRTLFSFLGDIEELRLYPP-DNAPLAFSSKVCYVKYREPSSV 63

  Fly    66 PVAQHLTNTVFIDRALIVIPVL--AIPEEYRALEML----KNGTIVPG---LQKP-DSKLPP--- 117
            .|||||||||||||||||:|..  .||||.:||.:|    ...:::||   |..| .:..||
 Frog    64 GVAQHLTNTVFIDRALIVVPCAEGKIPEETKALSLLAPAPSLSSLLPGAGLLPIPAPTPTPPIAS 128

  Fly   118 ---EVINRIEGQLP-----------------QQVIKTYDPKLVEF--------NLPEYPALPSFY 154
               .|:.|.:.::|                 :.||.|..|.|...        :||: |.|....
 Frog   129 SLASVLRREKVEVPLLSVPLTSLGVNLPTPLEPVITTLAPVLPALTPAIPAVADLPQ-PPLMGNV 192

  Fly   155 DARKIEEIRRTIIVCDVKNE-WRLDDLMECFQRAGEVKYARWA--EKDNKTYCMIEFCEQTSIIH 216
            |..|::||||||.|.::.:: ...:.|:|.|::.|:|::.|.|  |.....:..:||.:|.|:..
 Frog   193 DPTKVDEIRRTIYVGNLNSQTTTAEQLLEFFKQVGDVRFVRMAGDETQPTRFAFVEFSDQNSVTR 257

  Fly   217 ALRMQGQEFKGGHLSVYHSTYSITKPEAKSNEAAQAEIEEAMTIVKEAQSMISAAIDPVIGM-LA 280
            ||...|..|....|.:.||..:|.||...:.:||..|:||.|..|:||||.|||||:|..|. :.
 Frog   258 ALTFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPETGKPVE 322

  Fly   281 KDKRRRSRSRSRSRDRRTSRSRSHRSTSRRRSRRSGSRERRSVSRSRRSRSRGKHSSRSRS---- 341
            |.|:..|::|||||.:  ||||..||.|:.||.             .|:|||.:|..|.||
 Frog   323 KIKQEHSKTRSRSRSK--SRSRRKRSRSKNRSH-------------SRNRSRSRHKERRRSKSPH 372

  Fly   342 -KRSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGKR---------SRSRHRRSTSRSRSSRSHGTG 396
             |||:|:.||.|  ..|||||..|..:..:|:|:.         .:.:.:||.|.|:||.|.
 Frog   373 KKRSKSKDRRKS--KSRSRSRDRKKEKEYKSKGREKEKQKDKYDKKRKEKRSRSPSKSSSSI--- 432

  Fly   397 GGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSRS--KRSSPSPPPATGSKSRSSRSKDPVIVSAK 459
                   :||:|..|.|:..|| :..|:|||:..  ||||.||.|.  ||:|..:         |
 Frog   433 -------RRSQSASREKRKRRS-RSLSKSPRTSKTLKRSSRSPSPR--SKNRKEK---------K 478

  Fly   460 SSRRRDRSRTPETRKLKSISEDTEVKSSRSSAD----SKSRKSVSVEKSDNM 507
            ..:.||.:.....|:.....:.::|:..:.:||    ..|.|..|.::.:||
 Frog   479 KGKERDHNGNRHEREHSGSQKRSKVQERKEAADHYNTKLSEKHHSKDERNNM 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:409704	46/75 (61%)
		RRM2_SREK1	160..242	CDD:409705	27/84 (32%)
srek1	XP_002934235.1	RRM1_SREK1	8..87	CDD:409941	47/79 (59%)
		RRM2_SREK1	198..283	CDD:409705	27/84 (32%)