Protein Alignment Etl1 and Chd6

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_775544.2
• Gene: Chd6 / 71389
• MGIID: 1918639
• Length: 2711
• Species: Mus musculus
• Alignment Length: 932
• Identity: 265/932 - (28%)
• Similarity: 401/932 - (43%)
• Gaps: 205/932 - (21%)

  Fly    41 PSRTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKEKEERYM--AAAKISPHFDTMAIQES 103
            |...|...|.|..:.......:..:.:.|::.|.....||.:|...  ...|...|.:....:|.
Mouse   101 PGEQEGTKGSKDREPKPKRKREPKEPKEPRRAKEPKRAKEPKETKQKDGVKKPRKHREASGTKEG 165

  Fly   104 LSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYD 168
            ..:.:.....|....::..:.:|.. |:.:.|...|.|..:..:. :.|||..:...||.::..:
Mouse   166 KEKRSCTDYGSRTKSKKASREQGPT-PVERKKKGKRKNETTVESL-ELDHSLPNPSLQSPEEPSE 228

  Fly   169 SDDSDSEMSTKMTGQRK-------KVFQFMNE-----------------------------ASLI 197
            |.||....|.:...:||       ||.....|                             |::|
Mouse   229 SADSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANII 293

  Fly   198 E-LQSVKTLSE--------KKALAIIDVRPFS----DWSDLR---------QKLESIR------- 233
            | :.:.||:.|        ...|..:..|.||    .|:.:.         ||::..|
Mouse   294 EKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMK 358

  Fly   234 -----MSGDLLN-------------YAQELINKQNTVAAILSKCN-------------------- 260
                 ...||.|             :.::....:.....::..|:
Mouse   359 HIFTEPDEDLFNPDYIEIDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDPAKVK 423

  Fly   261 --------NMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMG 317
                    ..|..:|:..|:....:|..:...:..:|.:||:.|:|||........|.|||||||
Mouse   424 EFESLQILPEVKHVERPASDAWQKLETSREYRNSNRLREYQLEGMNWLLFNWYNRKNCILADEMG 488

  Fly   318 LGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERR----- 377
            ||||||.||||:.:...|: ....||:.|.||:.|||.|...| .|:....|||||..|:
Mouse   489 LGKTIQSIAFLSEIFVRGI-HGPFLIIAPLSTITNWEREFRTW-TEMNAIVYHGSQISRQMIQQY 551

  Fly   378 RMRGRFAK----DGFTGFDVLLTTYH-IVGSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYAN 437
            .|..|.|:    .|...|.|::||:. |:...||.:|:...|    ||.||||.|||...:....
Mouse   552 EMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSC----VIIDEAHRLKNRNCKLLEG 612

  Fly   438 LITINARMRILLTGTPLQNNLLELISLLCFVMPK------FFAKSIEDIKSLFAKKGKSDGDQDE 496
            |..:....::|||||||||::.||.|||.|:.|.      .|.:...|:|:
Mouse   613 LKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKT-------------- 663

  Fly   497 VSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGE 561
                 |.|:::.:.|:||.:|||||.||.|||..|...:.:|.:::.||.||..:::   .|...
Mouse   664 -----EEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILE---KNFSF 720

  Fly   562 VCSSSERAG----IAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELA 622
            :...:.:..    |..|||:|:..|||.|         :.|..:::  ...|:|.:.       :
Mouse   721 LTKGANQHNMPNLINTMMELRKCCNHPYL---------INGAEEKI--LEDFRKAHS-------S 767

  Fly   623 VMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEY 687
            ..||||:..|:..               :||.:.:|.|||||.|.||:||:|||....|||:|:|
Mouse   768 EASDFQLQAMIQA---------------AGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDY 817

  Fly   688 LRIRKFGFCRLDGATAVNVRQDLITDF-NGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNP 751
            |..|::.:.|:||....|:||..|..| ..|...|||||.|:|||:||||||||||:|.|.|:||
Mouse   818 LIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNP 882

  Fly   752 YNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITS--NEKGEVHEQRCVV 814
            .||.||:.||||:||.:.|.:||||:.::.|..:...|..||.|:|.|..  |.||..:..:.:.
Mouse   883 QNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAILQDINRKGSTNGVQQLS 947

  Fly   815 K------LLTTALGLDKDQEEQ 830
            |      |...|.|...|:|::
Mouse   948 KMEVEDLLRKGAYGALMDEEDE 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	14/91 (15%)
		HepA	<276..795	CDD:440319	200/539 (37%)
Chd6	NP_775544.2	Required for DNA-dependent ATPase activity. /evidence=ECO:0000250	1..746		166/674 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..243		27/143 (19%)
		PTZ00449	<101..372	CDD:185628	49/272 (18%)
		CD1_tandem_CHD5-9_like	287..352	CDD:349315	13/64 (20%)
		CD2_tandem_CHD5-9_like	371..429	CDD:349310	1/57 (2%)
		PLN03142	459..>984	CDD:215601	211/572 (37%)
		DEAD-like_helicase_N	460..681	CDD:475120	91/245 (37%)
		DEAH box	597..600		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1318..1389
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1951..1978
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1997..2059
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2124..2147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2321..2350
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2373..2419
		BRK	2402..2435	CDD:470653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2550..2602
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2641..2711