DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Etl1 and SMARCA2

DIOPT Version :10

Sequence 1:NP_609320.2 Gene:Etl1 / 34311 FlyBaseID:FBgn0032157 Length:844 Species:Drosophila melanogaster
Sequence 2:NP_003061.3 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens


Alignment Length:889 Identity:275/889 - (30%)
Similarity:413/889 - (46%) Gaps:196/889 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 RINKNASSVVASPSR-----TERVPGKKRIQVMADSDSDG------------------------- 63
            :::|..::..|:..|     |||:..::..::||: |.:|                         
Human   475 KLSKAVATWHANTEREQKKETERIEKERMRRLMAE-DEEGYRKLIDQKKDRRLAYLLQQTDEYVA 538

  Fly    64 ---------NDSQTPKKTKLELTVKEKEERYMAAAKISPHFDTMAIQESLSRTNWDVAASVRYLR 119
                     ..:|..|:.|.....|:|.|......:.:...|...|.||...:  |:...|.:..
Human   539 NLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMS--DLPVKVTHTE 601

  Fly   120 ENCKPKGHNGPLAKS-----KLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYDSDDSDSEMSTK 179
            ......|...|.|..     ::.|   |......||::.||.|         |:.:|.:.|.|.:
Human   602 TGKVLFGPEAPKASQLDAWLEMNP---GYEVAPRSDSEESDSD---------YEEEDEEEESSRQ 654

  Fly   180 MTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMSGD---LLNY 241
            .|          .|..|::..| :.:|||               |.:|.:|:.:...|   .:.|
Human   655 ET----------EEKILLDPNS-EEVSEK---------------DAKQIIETAKQDVDDEYSMQY 693

  Fly   242 AQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQ 306
            :........|||..:|:      |:||          |..||.:| .|..||:.||.|:..::..
Human   694 SARGSQSYYTVAHAISE------RVEK----------QSALLING-TLKHYQLQGLEWMVSLYNN 741

  Fly   307 EMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHG 371
            .:|||||||||||||||.||.:.||.|:......:||:||.|||.||..|..:|.|.:|...|.|
Human   742 NLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKG 806

  Fly   372 SQDERRRM--RGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHMLKN---MT 431
            :...||.:  :.|..|     |:||||||..:   .:::.:....:..|:|.||.|.:||   ..
Human   807 TPAMRRSLVPQLRSGK-----FNVLLTTYEYI---IKDKHILAKIRWKYMIVDEGHRMKNHHCKL 863

  Fly   432 TQRYANLITIN----ARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDG 492
            ||      .:|    |..|||||||||||.|.||.:||.|::|..| ||....:..|.......|
Human   864 TQ------VLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTG 921

  Fly   493 DQDEVSQFQET--QIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYY 555
            ::.:::: :||  .|:|..::::||:||||||:|...||:|:..|.|..||:.|||.|..:    
Human   922 ERVDLNE-EETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHM---- 981

  Fly   556 SNNKGEVC---SSSERAG-------IAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFK 610
             ..||.:.   |..::.|       :..:|::|:|.|||.:.:|.                    
Human   982 -QAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHI-------------------- 1025

  Fly   611 KTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFS 675
               |:...|.|...:.     ::|..|.|..         ||||..||.:||||:|..||||||.
Human  1026 ---EESFAEHLGYSNG-----VINGAELYRA---------SGKFELLDRILPKLRATNHRVLLFC 1073

  Fly   676 QFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGVGINLTAA 739
            |.|.::.|:|:|...|.|.:.||||.|....|..|:..||...| .|:|||||:|||:|:||.||
Human  1074 QMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAA 1138

  Fly   740 DTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITS--- 801
            ||.||.|.|:||:.|.||:||.||:|||..|.:.||.:.:::||.||.||:.||.:::.:..   
Human  1139 DTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGM 1203

  Fly   802 -NEKGEVHEQRCVVKLLTTALGLDKDQEEQ----LNNSLNNSIA 840
             ::|...||:|.   .|...|..:::.||:    .:.:||..||
Human  1204 FDQKSSSHERRA---FLQAILEHEEENEEEDEVPDDETLNQMIA 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Etl1NP_609320.2 ComEA <192..233 CDD:441164 9/40 (23%)
HepA <276..795 CDD:440319 208/540 (39%)
SMARCA2NP_003061.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Atrophin-1 <46..>450 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176
QLQ 173..207 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334
HSA 436..508 CDD:214727 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 10/42 (24%)
BRK 589..632 CDD:462196 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 14/64 (22%)
DEXHc_SMARCA2 701..951 CDD:350821 106/282 (38%)
PLN03142 720..>1202 CDD:215601 205/540 (38%)
DEGH box 851..854 2/2 (100%)
SnAC 1259..1326 CDD:464219
Bromodomain 1333..>1419 CDD:445827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383
Bromo_SNF2L2 1382..1506 CDD:99947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590
Blue background indicates that the domain is not in the aligned region.

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