DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Etl1 and Hel89B

DIOPT Version :9

Sequence 1:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	226/882 - (25%)
Similarity:	367/882 - (41%)	Gaps:	239/882 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TMAIQESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNG-------ISGGNFSDN--- 151
            |:|:|::::.||....|.           |...|.|.:  .||..|       :|..|.:.:
  Fly  1042 TLALQQTVTTTNTRSGAG-----------GATTPTATT--APRGPGRPPTGEILSATNATAHIEL 1093

  Fly   152 --DHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQR-------------KKVFQFMNEA------S 195
              ..:.:.:.||.:.|...:..: .|...::.|::             .||.||:.||      |
  Fly  1094 KAQQAKEAEAKQCRIQRLGAACA-IEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGS 1157

  Fly   196 LI-------ELQSVKTLSEKKA-----------------LAIIDVRPFSDWSDLRQKLESIRMSG 236
            |:       ||.|...|.|..|                 |..|...|......:..:..::....
  Fly  1158 LLPDLGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEI 1222

  Fly   237 D--------------LLNYAQELINKQNTVAAILSKCNNMVSRLE-KAISN---------GA--- 274
            |              ||...::||.:|..:.||    ..:||||: |.:..         ||
  Fly  1223 DACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI----ERVVSRLQIKVVPYIVLLVVPLLGAMSD 1283

  Fly   275 -----------------------GIVEQ----------------------PKLLSS-------GL 287
                                   |..||                      ||.:.:       .:
  Fly  1284 PDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISV 1348

  Fly   288 QLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLA----YLKENGLSQAAHLIVVPSS 348
            :|..||..|:|||..::|..::|||.|:||||||:|.|..||    :.:...|:....|::.|.:
  Fly  1349 ELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPT 1413

  Fly   349 TLDNWEAEISRWCPELVVEK---YHGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERK- 409
            ...:|..|:.::..:..|.:   |:|....|.::|    .|..|..::::.:|..|      ||
  Fly  1414 LTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLR----SDIGTKCNLVVASYDTV------RKD 1468

  Fly   410 --MFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKF 472
              .|.....:|.:.||.|::||..|:....:..:.|..|::|:|||:|||:|||.||..|:||.|
  Fly  1469 IDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGF 1533

  Fly   473 FAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQI---QRAKRIMKPFVLRRLKKDVLKNLPKKLS- 533
            .....:.::. |::...|..|....::.||..:   :...|.:.||:|||:|:||||:||.|::
  Fly  1534 LGTEKQFVQR-FSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQ 1597

  Fly   534 --LVEKVPMSSQQKIYYHELVDYYSNNKGEVC------SSSE-------RAGIAIMMEMR---RI 580
              |.|..|:  |.::|     :.:||...:.|      |||.       .|...|...:|   .:
  Fly  1598 DLLCELSPL--QLRLY-----EDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNV 1655

  Fly   581 ANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIP- 644
            .|||.|:               |..:....|...|..... :.:.|.:          :..|:|
  Fly  1656 CNHPKLV---------------LRQSEELTKVTSQLALSN-SSLDDIE----------HSAKLPA 1694

  Fly   645 -DNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYL---RIRKFGFCRLDGATAVN 705
             ..|:.|.|..:..:::      ..||.|:|.|...||||||:.|   .:....:.||||:...:
  Fly  1695 LKQLLLDCGIGVQTESV------SQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPAS 1753

  Fly   706 VRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPV 770
            .|||::.:||.|.||.|.||:|..||:|:|||.|||.:..:.|:||..|.||.||.||:||::.|
  Fly  1754 QRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVV 1818

  Fly   771 TIYRLISESTIEEGILMAAEEKLKLEKDITSNEKGEV 807
            .:||||:.:::||.|:...:.|:.....:.|.|...:
  Fly  1819 NVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASL 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	99/326 (30%)
		DEXDc	308..453	CDD:238005	42/154 (27%)
		Helicase_C	651..765	CDD:278689	48/116 (41%)
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874	19/109 (17%)
		HEAT repeat	1234..1261	CDD:293787	8/30 (27%)
		HEAT repeat	1269..1298	CDD:293787	2/28 (7%)
		SNF2_N	1353..1662	CDD:278600	99/326 (30%)
		DEXDc	1370..1514	CDD:238005	42/153 (27%)
		Helicase_C	1689..1813	CDD:278689	52/129 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467149
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950