DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Etl1 and brm

DIOPT Version :9

Sequence 1:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	880	Identity:	268/880 - (30%)
Similarity:	418/880 - (47%)	Gaps:	196/880 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DLRQF---------RINKNASSVVASPSR-----TERVPGKKRIQVMADSDSDG----------- 63
            |||:|         |:||...:..|:..|     .||:..::..::||: |.:|
  Fly   526 DLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAE-DEEGYRKLIDQKKDK 589

  Fly    64 --------------NDSQTPKKTKLELTVKEKEE--RYMAAAKISPHFDTMAIQESLSRTNWDVA 112
                          |.:|..|:.|.:...|::||  |.:...|     :.:...|.:......:.
  Fly   590 RLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKK-----ELLMSGEYIGIDEGSIV 649

  Fly   113 ASVR-YLRENCKPK---GHNGPLAKSKLKPRSNGISGGNFSDNDH----SDDDDVKQSKDQVYDS 169
            |.:| ::.|.|..|   |.:.|:.| .|....|...|.::.|::.    |:||...:.::|...:
  Fly   650 ADMRVHVVEQCTGKKLTGDDAPMLK-HLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTAT 713

  Fly   170 DDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDL--RQKLESI 232
            :|:..:  .:.||..:                                   |..||  :.|:|.
  Fly   714 EDATDK--AQATGNDE-----------------------------------DAKDLITKAKVED- 740

  Fly   233 RMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGL 297
                      .|...::.|..:|....:      ||       :|||..::.:| .|.:|||.||
  Fly   741 ----------DEYRTEEQTYYSIAHTIH------EK-------VVEQASIMVNG-TLKEYQIKGL 781

  Fly   298 NWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCP 362
            .||..::...:|||||||||||||||.|:.:.||.:.......:||:||.|||.||..|..:|.|
  Fly   782 EWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAP 846

  Fly   363 ELVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHML 427
            .:.|..|.||...||.::.:...   |.|:||||||..|   .:::.:....:..|:|.||.|.:
  Fly   847 AVGVVSYKGSPQGRRLLQNQMRA---TKFNVLLTTYEYV---IKDKAVLAKIQWKYMIIDEGHRM 905

  Fly   428 KN----MTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKG 488
            ||    :|.....:.|   |..|:|||||||||.|.||.:||.|::|..| ||....:..|....
  Fly   906 KNHHCKLTQVLNTHYI---APYRLLLTGTPLQNKLPELWALLNFLLPSIF-KSCSTFEQWFNAPF 966

  Fly   489 KSDGDQDEVSQFQET--QIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHE- 550
            .:.|::.|::: :||  .|:|..::::||:||||||:|...||.|:..:.|..||:.|::.|..
  Fly   967 ATTGEKVELNE-EETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHM 1030

  Fly   551 ------LVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSF 609
                  |.|  .:.||:......:|.:..::::|::.|||.:.:|
  Fly  1031 QSKGVLLTD--GSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQH-------------------- 1073

  Fly   610 KKTNEQYIFEE--LAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVL 672
              ..|:|....  ..|:|...:|::                  ||||..||.:||||||..||||
  Fly  1074 --IEEKYCDHTGGHGVVSGPDLYRV------------------SGKFELLDRILPKLKATNHRVL 1118

  Fly   673 LFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGVGINL 736
            ||.|.|..:.|:|:||..|:||:.||||.|....|.:|:..||...| :|||||||:|||:|:||
  Fly  1119 LFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNL 1183

  Fly   737 TAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITS 801
            ..|||.||.|.|:||:.|.||:||.||:||:..|.:.||::.:::||.||.||..||.:::.:..
  Fly  1184 QTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ 1248

  Fly   802 ----NEKGEVHEQRCVVKLLTTALGLDKDQEEQLN 832
                ::|....|::   :.|.|.|..|.::||:.|
  Fly  1249 AGMFDQKSTGSERQ---QFLQTILHQDDNEEEEEN 1280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	115/307 (37%)
		DEXDc	308..453	CDD:238005	60/148 (41%)
		Helicase_C	651..765	CDD:278689	66/114 (58%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	11/46 (24%)
		BRK	649..693	CDD:197800	12/44 (27%)
		PHA02934	687..>824	CDD:165245	48/198 (24%)
		SNF2_N	776..1071	CDD:278600	115/307 (37%)
		DEXDc	793..932	CDD:238005	60/147 (41%)
		Helicase_C	1097..1212	CDD:278689	66/114 (58%)
		SnAC	1304..1375	CDD:291293
		Bromo_SNF2L2	1425..1530	CDD:99947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467143
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940