DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Etl1 and Iswi

DIOPT Version :9

Sequence 1:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	235/703 - (33%)
Similarity:	342/703 - (48%)	Gaps:	136/703 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 DNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLI----ELQSVKTLSEKKA 210
            :|.:....|...|     .|.:.::|...|:...|.:.|.|:.:.:.|    ...|.|:.::.|.
  Fly    14 ENSNETTSDAATS-----SSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKG 73

  Fly   211 --LAIIDVRPFSDWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNG 273
              ..|.|.....|.:|.|.:........:||  |::...|:             :.|.:.:
  Fly    74 RPKKIKDKDKEKDVADHRHRKTEQEEDEELL--AEDSATKE-------------IFRFDAS---- 119

  Fly   274 AGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQ 338
                  |..:.|| ::.||||.||||:..:::..:|||||||||||||:|.|:.|.|||......
  Fly   120 ------PAYIKSG-EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQA 177

  Fly   339 AAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFT--GFDVLLTTYHIV 401
            ..|:::||.|||.||..|..:|||.|......|.||    .|..|.:|...  .:||.:|:|.:
  Fly   178 GPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQD----TRNTFIRDVLMPGEWDVCVTSYEM- 237

  Fly   402 GSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLC 466
              ...|:.:|:.....|::.||||.:||..::....|.......|:|:|||||||||.||.:||.
  Fly   238 --CIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLN 300

  Fly   467 FVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKK 531
            |::|..| .|.||....| ......||        :..|.|...::|||:|||||.:|.|.|..|
  Fly   301 FLLPDVF-NSSEDFDEWF-NTNTCLGD--------DALITRLHAVLKPFLLRRLKAEVEKRLKPK 355

  Fly   532 LSLVEKVPMSSQQKIYYHEL----VDYYSNNKGEVCSSSERAGIA-IMMEMRRIANHPLLM---- 587
            ..:...|.:|..|:.:|.::    :|.. |..|:|    |:..:. |:|::|:..|||.|.
  Fly   356 KEMKIFVGLSKMQRDWYTKVLLKDIDVV-NGAGKV----EKMRLQNILMQLRKCTNHPYLFDGAE 415

  Fly   588 --RHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICD 650
              ..|.||.:|                                ||                   :
  Fly   416 PGPPYTTDTHL--------------------------------VY-------------------N 429

  Fly   651 SGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFN 715
            |||...||.|||||:.:|.|||:|||.|.||||:|:|...|.:.:|||||.|....|...|.:||
  Fly   430 SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFN 494

  Fly   716 GDDSI-FVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISES 779
            .|:|. |:|:|||:|||:||||..||..:|:|.|:||..|.||.||.||:||::.|.::|||:||
  Fly   495 MDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITES 559

  Fly   780 TIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLN 832
            |:||.|:..||.||:|:|.:.  :.|.:.:.|        :..|:||  |.||
  Fly   560 TVEEKIVERAEVKLRLDKMVI--QGGRLVDNR--------SNQLNKD--EMLN 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	112/301 (37%)
		DEXDc	308..453	CDD:238005	56/146 (38%)
		Helicase_C	651..765	CDD:278689	63/114 (55%)
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	7/36 (19%)
		SNF2_N	131..411	CDD:278600	112/301 (37%)
		DEXDc	148..287	CDD:238005	56/145 (39%)
		HELICc	422..553	CDD:238034	71/181 (39%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467141
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950