Protein Alignment Etl1 and Chd7

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 964
• Identity: 279/964 - (28%)
• Similarity: 429/964 - (44%)
• Gaps: 241/964 - (25%)

  Fly    13 SASSSAKSSLSD-----LRQFRINKNASSVVASPSRTERVPGKKRIQVMADSDSDGNDSQTPKKT 72
            :|..|:|....|     :....:.:|:..|.....:.::.|..|:....:....:..:.:|||..
Mouse   600 AAGDSSKGFGKDDFPGGVENQELRRNSLDVSQEEKKKKKRPKVKKDPKESKEPKEKKEPKTPKAP 664

  Fly    73 KLELTVKEKEERYMAAAKISPHFDTMAIQESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLK 137
            |:....|||:     |..::|.      .:|..:::            |.||......|.|...|
Mouse   665 KIPKEPKEKK-----AKTVTPK------PKSSKKSS------------NKKPDSEASALKKKVNK 706

  Fly   138 PRSNGISGGNF-----------SDND----------------HSDDDDVKQSKDQVYDSDDS--D 173
            .::.|....:.           .|.|                :::|.:.|.|.::..|:|.:  |
Mouse   707 GKTEGSENSDLDKTPPPSPAPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRD 771

  Fly   174 SEMSTKMTGQRKKVFQFMNEASLIE--LQSVKTLSEKKALAIIDVRPF-----------SDWSD- 224
            |..:|..:.|::.|..   |..::|  :.|.....:|::...::|..|           ..|:.
Mouse   772 SPSNTSQSEQQESVDA---EGPVVEKIMSSRLVKKQKESGEEVEVEEFYVKYKNFSYLHCQWASV 833

  Fly   225 --------LRQKLESIR-----------MSGDLLN-----------YAQELINKQNTVAAILSK- 258
                    ::||::..:           :..||.|           :|:...::...|...|.|
Mouse   834 EDLEKDKRIQQKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDFARSTDDRGEPVIHYLVKW 898

  Fly   259 CN----------------NMVSRLEKAISNGAGI--VEQP-----------KLLSSGLQLADYQI 294
            |:                ..:...||.:|.....  ||:|           :...:..:|.:||:
Mouse   899 CSLPYEDSTWELKQDIDQTKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQL 963

  Fly   295 IGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFL--AYLKENGLSQAAHLIVVPSSTLDNWEAEI 357
            .|:|||........|.|||||||||||||.|.||  .|||  |: ....|::.|.||:.|||.|.
Mouse   964 EGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLK--GI-HGPFLVIAPLSTIPNWEREF 1025

  Fly   358 SRWCPELVVEKYHGSQDERRRM----------RGRFAKDGFTGFDVLLTTYH-IVGSTPEERKMF 411
            ..| .||.|..|||||..||.:          :||..|..:. |..::||:. |:...||.|.:.
Mouse  1026 RTW-TELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYK-FHAIITTFEMILTDCPELRNIP 1088

  Fly   412 RVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMP-KF--- 472
            ..|    |:.||||.|||...:....|..::...::|||||||||.:.||.|||.|:.| :|
Mouse  1089 WRC----VVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSE 1149

  Fly   473 --FAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNL-PKKLSL 534
              |.:...|:|:                   |.|:|:.:.|:||.:|||||:||.||| ||:.::
Mouse  1150 TTFMQEFGDLKT-------------------EEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETI 1195

  Fly   535 VEKVPMSSQQKIYYHELVD----YYSNNKGEVCSSSERAGIA----IMMEMRRIANHPLLMRHYF 591
            :| |.:::.||.||..:::    :.|...|:       |.:.    .|||:|:..|||.|
Mouse  1196 IE-VELTNIQKKYYRAILEKNFTFLSKGGGQ-------ANVPNLLNTMMELRKCCNHPYL----- 1247

  Fly   592 TDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLY 656
                :.|..:::  ...||:|:.       |...|||:..|:..               :||.:.
Mouse  1248 ----INGAEEKI--LEEFKETHN-------AESPDFQLQAMIQA---------------AGKLVL 1284

  Fly   657 LDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-I 720
            :|.|||||||.|||||:|||....|||:|:||..|::.:.|:||....|:||..|..|:..|| .
Mouse  1285 IDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDR 1349

  Fly   721 FVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGI 785
            |||||.|:|||:||||||||||:|.|.|:||.||.||:.||||:||.:.|.|||||:.::.|..:
Mouse  1350 FVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREM 1414

  Fly   786 LMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTT---------ALGLDKDQEEQ 830
            ...|..||.|:|.:..:..|..:....|.:|...         |.|...|:|::
Mouse  1415 FDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDE 1468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	9/62 (15%)
		HepA	<276..795	CDD:440319	213/560 (38%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792		38/217 (18%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	9/66 (14%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	7/56 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		3/20 (15%)
		PLN03142	957..>1556	CDD:215601	219/581 (38%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986