Protein Alignment Etl1 and Ercc6

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001423629.1
• Gene: Ercc6 / 306274
• RGDID: 1311509
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 829
• Identity: 232/829 - (27%)
• Similarity: 363/829 - (43%)
• Gaps: 198/829 - (23%)

  Fly    40 SPSRTERVPGKKRIQVMADSDSD-----GNDSQTPKKTKLELTVKEKEERYMAAAKIS--PHFDT 97
            :|.:.|:.|.|    :|.:..|.     .:.:|...|.|.:...|...::.:..::.|  |: :|
  Rat   253 APQKQEKKPRK----IMLNEASGFEKYLADQAQLSFKRKKQAANKRTAKKAVVVSESSRGPN-ET 312

  Fly    98 MAIQES--LSRTNWDVAASVRYL-RENCKPKGHNG------PLAKSKLKPRSNGISGGNFSDNDH 153
            ...|.|  ||:|:..:...:|.| |...:.:|..|      ||...: :|.:.|.:.|..|.:..
  Rat   313 KPNQRSQALSQTDKRLKKHIRKLQRRALQFQGKVGLQRGKRPLEPEE-RPGAEGDTEGEESGSSP 376

  Fly   154 SDDDDVKQSKDQ---VYDSDDSDSEMSTKMTGQR--KKVFQFMNEASLIELQSVK----TLSEKK 209
            :|.::.::.:::   |..|||...|:.....||:  |||          .:|.:.    ..||::
  Rat   377 TDGEEEEEQEEEGVAVLSSDDISYELKPLRKGQKYEKKV----------PVQEIDDDFFPSSEEE 431

  Fly   210 ALAI--------IDVRP-----------FSDWSDLR-QKLESIRMSGDLLNYAQELINKQNTVAA 254
            ..|:        :..||           ...|:.|| |..|.:::..|......| .::...|..
  Rat   432 DEAVEGRGGGRKVSRRPDDGDEDYYKQRLRRWNRLRLQDKEKLKLEDDSEESDAE-FDEGFKVPG 495

  Fly   255 ILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLG 319
            .|.|                             :|..||..|:.||..:|.|:..|||.||||||
  Rat   496 FLFK-----------------------------KLFKYQQTGVRWLWELHCQQAGGILGDEMGLG 531

  Fly   320 KTIQVIAFLAYL------------KENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYH-- 370
            ||||:|||||.|            :..||...  |||.|::.:..|..|...|.|...|...|
  Rat   532 KTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPT--LIVCPTTVMHQWVKEFHTWWPPFRVAILHET 594

  Fly   371 GSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLD--YVIFDEAHMLKNMTTQ 433
            ||...|:.   |..:|......||:|:|..:....::     :.:.|  |||.||.|.::|...
  Rat   595 GSCAHRKE---RLVRDIVHCHGVLITSYSYIRLMQDD-----ISRHDWHYVILDEGHKIRNPNA- 650

  Fly   434 RYANLITINARM-----RILLTGTPLQNNLLELISLLCF-------VMPKFFAKSIEDIKSLFAK 486
                .:|:..:.     ||:|:|:|:||||.||.||..|       .:|.|    :|........
  Rat   651 ----AVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFTFPGKLGTLPVF----MEQFSVPITM 707

  Fly   487 KGKSDGDQDEVSQFQETQIQRA---KRIMKPFVLRRLKKDVLK--NLPKKLSLVEKVPMSSQQKI 546
            .|.|:....:|    :|..:.|   :..:.|::|||:|.||..  :||.|...|....::.:|..
  Rat   708 GGYSNASPVQV----KTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHK 768

  Fly   547 YYHELVDYYS-----NNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANA 606
            .|...:|..:     |.:.::.|.        ::.:|:|.|||.|            ||....|.
  Rat   769 VYQNFIDSKAVYRILNGENQIFSG--------LVALRKICNHPDL------------FSGGPKNT 813

  Fly   607 SSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRV 671
            |:..   |..:.||     .|..::.                  |||.:.:::||.....:|.||
  Rat   814 SALP---EDGLEEE-----QFGYWKR------------------SGKMIVVESLLKIWHKQGQRV 852

  Fly   672 LLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAGGVGINL 736
            |||||...||.|:|.:||..|:.:.::||.|.:..||.|||.:|.|.|||||||:|:.||:|:||
  Rat   853 LLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNL 917

  Fly   737 TAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGI 785
            |.|:..:|:|.|:||..|.||.:|..|:||::.||:|||::..||||.|
  Rat   918 TGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKI 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	11/64 (17%)
		HepA	<276..795	CDD:440319	176/548 (32%)
Ercc6	NP_001423629.1	cc_ERCC-6_N	83..159	CDD:411064
		HepA	316..981	CDD:440319	219/761 (29%)
		CSB_WHD	1402..1473	CDD:439329