Protein Alignment Etl1 and Smarca4

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_011240739.1
• Gene: Smarca4 / 20586
• MGIID: 88192
• Length: 1670
• Species: Mus musculus
• Alignment Length: 906
• Identity: 259/906 - (28%)
• Similarity: 411/906 - (45%)
• Gaps: 208/906 - (22%)

  Fly    24 DLRQF------RINKNASSVVASPSRTERVP-------GKKRIQVMADSDSDG------------ 63
            |.|::      ::.|...:|....:.|||..       .|:|::.:...|.:|
Mouse   505 DFREYHRSVTGKLQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKR 569

  Fly    64 -------------NDSQTPKKTKLELTVKEKEERYMAAAKISPHFDTMAI---QESLSRTNW--D 110
                         |.::..::.|.....|||:::.......:....|.||   .|.|..|:.  |
Mouse   570 LAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSD 634

  Fly   111 VAASVRYLRENCKPKGHNGPLAKS-----------KLKPRSNGISGGNFSDNDHSDDDDVK---- 160
            :...|.::.......|.:.|.|..           ::.|||:....|:..:.:..:::..:
Mouse   635 LPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQP 699

  Fly   161 -----QSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFS 220
                 :.|.::.|.|..|                               :||..|..||:
Mouse   700 PTLPVEEKKKIPDPDSDD-------------------------------VSEVDARHIIE----- 728

  Fly   221 DWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSS 285
               :.:|.::      |....:|.|.....:..|:   .:.:..|::|          |..|:.:
Mouse   729 ---NAKQDVD------DEYGVSQALARGLQSYYAV---AHAVTERVDK----------QSALMVN 771

  Fly   286 GLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTL 350
            |: |..|||.||.||..::...:|||||||||||||||.||.:.||.|:.......||:||.|||
Mouse   772 GV-LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTL 835

  Fly   351 DNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFTG-FDVLLTTYHIVGSTPEERKMFRVC 414
            .||..|..:|.|.:|...|.||...||    .|.....:| |:||||||..:   .:::.:....
Mouse   836 SNWAYEFDKWAPSVVKVSYKGSPAARR----AFVPQLRSGKFNVLLTTYEYI---IKDKHILAKI 893

  Fly   415 KLDYVIFDEAHMLKN---MTTQRYANLITIN----ARMRILLTGTPLQNNLLELISLLCFVMPKF 472
            :..|:|.||.|.:||   ..||      .:|    |..|:|||||||||.|.||.:||.|::|..
Mouse   894 RWKYMIVDEGHRMKNHHCKLTQ------VLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTI 952

  Fly   473 FAKSIEDIKSLFAKKGKSDGDQDEVSQFQET--QIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLV 535
            | ||....:..|.......|::.:::: :||  .|:|..::::||:||||||:|...||:|:..|
Mouse   953 F-KSCSTFEQWFNAPFAMTGEKVDLNE-EETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYV 1015

  Fly   536 EKVPMSSQQKIYYHELVDYYSNNKGEVC---SSSERAG-------IAIMMEMRRIANHPLLMRHY 590
            .|..||:.|::.|..:     ..||.:.   |..::.|       :..:|::|:|.|||.:.:|.
Mouse  1016 IKCDMSALQRVLYRHM-----QAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHI 1075

  Fly   591 FTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFL 655
                 ...||:.|....              .::....:|:.                  ||||.
Mouse  1076 -----EESFSEHLGFTG--------------GIVQGLDLYRA------------------SGKFE 1103

  Fly   656 YLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS- 719
            .||.:||||:|..|:||||.|.|.::.|:|:|...|.|.:.||||.|....|..|:..||...|
Mouse  1104 LLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSE 1168

  Fly   720 IFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEG 784
            .|:|||||:|||:|:||.:|||.:|.|.|:||:.|.||:||.||:|||..|.:.||.:.:::||.
Mouse  1169 YFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEK 1233

  Fly   785 ILMAAEEKLKLEKDITS----NEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSLNNSIAS 841
            ||.||:.||.:::.:..    ::|...||:|..::    |:...::|:|..:.|..:..||
Mouse  1234 ILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQ----AILEHEEQDESRHCSTGSGSAS 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	6/40 (15%)
		HepA	<276..795	CDD:440319	202/539 (37%)
Smarca4	XP_011240739.1	Med15	62..>237	CDD:312941
		QLQ	191..225	CDD:462622
		Smc	<384..>590	CDD:440809	12/84 (14%)
		HSA	480..552	CDD:214727	9/46 (20%)
		BRK	632..676	CDD:197800	7/43 (16%)
		DEXHc_SMARCA4	751..1001	CDD:350820	103/278 (37%)
		PLN03142	770..>1252	CDD:215601	200/539 (37%)
		SnAC	1342..1409	CDD:464219
		Bromo_SNF2L2	1481..1587	CDD:99947