DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Etl1 and Hltf

DIOPT Version :10

Sequence 1:NP_609320.2 Gene:Etl1 / 34311 FlyBaseID:FBgn0032157 Length:844 Species:Drosophila melanogaster
Sequence 2:NP_033236.2 Gene:Hltf / 20585 MGIID:1196437 Length:1003 Species:Mus musculus


Alignment Length:932 Identity:202/932 - (21%)
Similarity:350/932 - (37%) Gaps:273/932 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 ASPSRTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKE-KEERYMAAAKISPHFDTMAIQE 102
            |.||.:.  |....:|:..|.          .||:.:...:: ||:......:.:...:|..:..
Mouse   191 AGPSYSR--PAHVAVQMTTDQ----------LKTEFDKLFEDLKEDDRTVEMEPAEAIETPLLPH 243

  Fly   103 SLSRTNWDVAASVRYLRENCKPKG---------HNGPLAKSKLKPRSNGISGG------------ 146
            ......|.:|      |||.|...         :...:....:|.|...:.||            
Mouse   244 QKQALAWMIA------RENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTL 302

  Fly   147 --------NFSD----------NDHS----DDDDVKQSKDQVYDSDDSDSEMST-----KMTGQR 184
                    ||.|          .:|.    .|:.:|:....:...:|..||.||     .::|..
Mouse   303 TAIAVILTNFDDGRPLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTCGEEPSISGTP 367

  Fly   185 KKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFS--DWSDLRQKLESIRMSGDLLNYAQELIN 247
            :|     :..:|.:|.||.....|.::..|:.....  :.|:|.||     |.|.|.|.      
Mouse   368 EK-----SSCTLSQLSSVCPKRRKISVQYIESSDSEEIETSELPQK-----MKGKLKNV------ 416

  Fly   248 KQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGIL 312
            :.||.:.:  |.::.|....|..........|.|:|..|:.:.:                     
Mouse   417 QLNTKSRV--KGSSKVKEDSKFALTFFASATQRKMLKKGMSMME--------------------- 458

  Fly   313 ADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNW--------EAEISRWCPELVVEKY 369
                           .:...:.|....|.||:.|.|.|.||        ::|:     .|....|
Mouse   459 ---------------CSEACDTGERTRATLIICPLSVLSNWIDQFGQHVKSEV-----HLNFYVY 503

  Fly   370 HGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVG---STPEERKMFRVCKLDYVIFDEAHMLKNMT 431
            :|  .:|.|.....:|.     |::||||:|:.   .|.::..:..: |...||.||.|.::|..
Mouse   504 YG--PDRIRDSAWLSKQ-----DIILTTYNILTHDYGTKDDSPLHSI-KWLRVILDEGHAIRNPN 560

  Fly   432 TQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDGD--- 493
            .|:...::.:.|..|.:|||||:||:|.:|.|||.|:..|.|.                |.:   
Mouse   561 AQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLSFLKLKPFI----------------DREWWY 609

  Fly   494 ---QDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLK-----NLPKKLSLVEKVPMSSQQKIYYHE 550
               |..|:...|..::|.:.::|...|||.|...:|     .||::...::.:.:|.:::..|..
Mouse   610 RIIQRPVTTGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSEEERKIYQS 674

  Fly   551 LVDYYSNNKGEVCSS---SERAGIA-------IMMEMRRIANHPLLMRHYFTDANLRGFSKRLAN 605
            :     .|:|:....   :|...:|       :::.:|:|..|    .|..|:    |.|....:
Mouse   675 V-----KNEGKAAIGRYFTEGTVLAHYADVLGLLLRLRQICCH----THLLTN----GMSSSGPS 726

  Fly   606 ASSFKKTNEQYIFEELAVM----SDFQ------------------------VYQMMN-------- 634
            .|...:...:.:.|::.::    ||.:                        :.|:::        
Mouse   727 RSDTPEELRKMLIEKMKIILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKC 791

  Fly   635 ---KHEFYDVKI----PDNLICDSGK------------------FLYLDTLLPKLKAEGHRVLLF 674
               ::|.:...:    |:.|.|||.|                  .:.|.|..|.:|:     |:.
Mouse   792 PLCRNEIHGDNLLECPPEELACDSDKESSMEWKSSSKINALMHALIELRTKDPNIKS-----LVV 851

  Fly   675 SQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDD--SIFVFLLSTKAGGVGINLT 737
            ||||..|.::|..|:...|.|.||||:.|...|.:.|..|...:  |..:.|||.||||||:||.
Mouse   852 SQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQRFQNTEAGSPTIMLLSLKAGGVGLNLC 916

  Fly   738 AADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKL------- 795
            ||....:.|..:||..:.|..|||||:||::.|.|.:.|.:.::||.:|.....|..|       
Mouse   917 AASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNTKRDLAAGAFGT 981

  Fly   796 -EKDITSNEKGEVHEQRCVVKL 816
             :.|....::.:::|.|.::.|
Mouse   982 KKTDANDMKQAKINEIRTLIDL 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Etl1NP_609320.2 ComEA <192..233 CDD:441164 10/42 (24%)
HepA <276..795 CDD:440319 144/613 (23%)
HltfNP_033236.2 DNA-binding. /evidence=ECO:0000250 38..287 19/113 (17%)
HIRAN 60..153 CDD:400928
DEXHc_HLTF1_SMARC3 240..638 CDD:350829 101/486 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..373 10/60 (17%)
HepA <468..980 CDD:440319 140/558 (25%)
DEGH box 551..554 2/2 (100%)
RING-HC_HLTF 749..803 CDD:438172 4/53 (8%)
Interaction with SP1 and SP3. /evidence=ECO:0000250 919..1003 22/83 (27%)
Blue background indicates that the domain is not in the aligned region.

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