Protein Alignment Etl1 and let-418

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_504523.1
• Gene: let-418 / 178970
• WormBaseID: WBGene00002637
• Length: 1829
• Species: Caenorhabditis elegans
• Alignment Length: 789
• Identity: 231/789 - (29%)
• Similarity: 360/789 - (45%)
• Gaps: 132/789 - (16%)

  Fly    43 RTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKEKEERYMAAAKISPHFDTMAIQESLSRT 107
            |.:.:|..:.::...::.||....:.|:|.:     ..:|..:....|...::....:.|.|...
 Worm   378 RWKEIPYPEPLEAGKEASSDDAMLKPPRKME-----PRREREFFVKWKYLSYWQCSWVSEMLLEV 437

  Fly   108 NWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYDSDDS 172
            ::.:.. :.|.|:|           .|...|...    .:.:...|||:|..| .:::.|.....
 Worm   438 HFRMLI-LLYWRKN-----------DSDAPPEFE----ESVTSRHHSDNDPYK-LRERFYQYGIK 485

  Fly   173 DSEMSTKMTGQRKKVFQFMNEASLIELQ-----SVKTLSEKKA--------LAIIDVRPFSDWSD 224
            ...|         ::.:.:|..|..:.|     ..|.||..:|        :|..:......|..
 Worm   486 PEWM---------QIHRIINHQSYAKSQQDYLVKWKELSYDQATWERDDSNIANYEEAIIKYWQH 541

  Fly   225 LRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLS-SGLQ 288
            ...||..     |:....|::|.|......:..|.:....:..:.|........||..:: :|.:
 Worm   542 RESKLNE-----DIPKNVQKMIAKHREAKGLPPKEDEKKKKKREKIDIRKKYEVQPDYVTETGGK 601

  Fly   289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNW 353
            |..||:.|||||........:.|||||||||||:|.:.||..|.:.|..:...||..|.||:.||
 Worm   602 LHPYQLEGLNWLRHCWSNGTDAILADEMGLGKTVQSLTFLYSLMKEGHCKGPFLIAAPLSTIINW 666

  Fly   354 EAEISRWCPELVVEKYHGSQDER---RRMRGRFAKDGFTG--------------FDVLLTTYHIV 401
            |.|..:|||:..|..|.|.:|.|   |.....|.:.....              |.||||:|..:
 Worm   667 EREAEQWCPDFYVVTYVGLRDARVVLREHEFSFVEGAVRSGPKASKMKTTENMKFHVLLTSYETI 731

  Fly   402 GSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLC 466
            ..   ::.:....:...::.||||.|||..:..:.||.......|:|||||||||||.||..||.
 Worm   732 NM---DKTILSSIEWGALVVDEAHRLKNNQSLFFKNLNEYTIHYRVLLTGTPLQNNLEELFHLLN 793

  Fly   467 FVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKK 531
            |:..:.| ..:|...:.|          :|:|  :|.||::...::.|.:|||||.|||..:|.|
 Worm   794 FLSKERF-NQLEAFTAEF----------NEIS--KEDQIEKLHNLLGPHMLRRLKADVLTGMPSK 845

  Fly   532 LSLVEKVPMSSQQKIYYHELV----DYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFT 592
            ..|:.:|.:|:.||.:|..::    |..:...|    .::.:.:.::||:::..|||.|    |.
 Worm   846 SELIVRVELSAMQKKWYKNILTRNFDALNVKNG----GTQMSLMNVLMELKKCCNHPYL----FV 902

  Fly   593 DANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYL 657
            .|.|          .:.|:.|..|  |..|                        ||.:||||:.|
 Worm   903 KAEL----------EAPKEKNGMY--EGTA------------------------LIKNSGKFVLL 931

  Fly   658 DTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IF 721
            ..:|.|||..|||||:|||.|.||||:|:......:.:.|:||:....:|||.|..:|...: .|
 Worm   932 QKMLRKLKDGGHRVLIFSQMTRMLDIMEDLCEYEGYRYERIDGSIMGQMRQDAIDRYNAPGAQQF 996

  Fly   722 VFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGIL 786
            :|||||:|||:||||..|||.:|:|.|:||:||.||..|.||:||:..|.|||.:::.::||.|.
 Worm   997 IFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKKSVEEKIT 1061

  Fly   787 MAAEEKLKL 795
            ..|::|:.|
 Worm  1062 SVAKKKMLL 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	11/53 (21%)
		HepA	<276..795	CDD:440319	191/541 (35%)
let-418	NP_504523.1	CHDNT	95..147	CDD:462357
		PHD1_CHD_II	258..300	CDD:277006
		RanBP2-type Zn finger	295..323	CDD:275375
		PHD_SF	320..362	CDD:473978
		CD1_tandem_CHD3-4_like	370..448	CDD:349314	11/75 (15%)
		CD2_tandem_CHD3-4_like	486..539	CDD:349309	9/61 (15%)
		PLN03142	590..>1114	CDD:215601	192/541 (35%)
		DUF1087	1188..1235	CDD:461922
		CHDII_SANT-like	1276..1406	CDD:461920
		CHDCT2	1525..1673	CDD:462358