Protein Alignment Etl1 and Mi-2

DIOPT Version :10

• Sequence 1: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_061510532.1
• Gene: Mi-2 / 1280662
• VectorBaseID: AGAMI1_012829
• Length: 2152
• Species: Anopheles gambiae
• Alignment Length: 950
• Identity: 253/950 - (26%)
• Similarity: 391/950 - (41%)
• Gaps: 308/950 - (32%)

  Fly     4 STVAASASASASSSAKSS---------------LSDLR-------QFRINKNASSVVASPSRTER 46
            ||...:|:|:..|:.:..               :::|:       .||.....:.:...|...|.
Mosquito   568 STSKGAAAAAGGSTRRREYFVKWHEKSYWHCDWITELQLDVHHPLMFRYYTRKNDMEEPPKLEEA 632

  Fly    47 VPGK----KRIQVMADSDSDGNDSQTPKKTKLELTVKEKEERY------MAAAKISPHFDTMAIQ 101
            :..:    ||||.|.:::...|:      |:||    ||..||      :...::..| .||...
Mosquito   633 LDEEDNRYKRIQRMRETNCQLNE------TELE----EKYYRYGVKPEWLMVHRVINH-RTMRDG 686

  Fly   102 ESLSRTNW---------------DVAA---SVRY---LRENCKPKGHNGPLAKSKLKPRSNGISG 145
            .:|....|               |:|.   ::.|   ||.||                 |..|.|
Mosquito   687 RTLYLVKWRELSYDQATWEDEEDDIAGLKMAIEYYLDLRANC-----------------SQDIGG 734

  Fly   146 GNFSDNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKA 210
            ..                     |..|.|....|..|:|:                ::.|.|::.
Mosquito   735 SG---------------------SGGSGSSKKNKKKGRRR----------------LRELEEEER 762

  Fly   211 LAII---DVRPFSDWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISN 272
            .|.:   ...|....:||::|.|
Mosquito   763 TAGVKRYTPPPEKPTTDLKRKFE------------------------------------------ 785

  Fly   273 GAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLS 337
                |:.|.|..:|::|..||:.|:|||........:.|||||||||||||...||..|.:.|..
Mosquito   786 ----VQPPYLDETGMRLHPYQLEGINWLRYSWANGTDTILADEMGLGKTIQTATFLYSLYKEGHC 846

  Fly   338 QAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGR---FAKDGFTG--------- 390
            :...|:.||.||:.|||.|...|.|:.....|.|.::.|..:|..   |.:....|
Mosquito   847 RGPFLVAVPLSTIINWEREFETWAPDFYCITYVGDKESRAVIRENELSFEEGAVRGGKASRIRAS 911

  Fly   391 ---FDVLLTTYHIVGSTPEERKMFRVC--KLDY--VIFDEAHMLKNMTTQRYANLITINARMRIL 448
               |:||||:|.::       .:...|  .:|:  ::.||||.||:..::.:..|...|...::|
Mosquito   912 SIKFNVLLTSYELI-------SIDAACLGSIDWSVLVVDEAHRLKSNQSKFFKVLNAYNIAYKLL 969

  Fly   449 LTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQ--------ETQI 505
            ||||||||||.||..||.|:.           ||.|          :|:::||        |.|:
Mosquito   970 LTGTPLQNNLEELFHLLNFLN-----------KSKF----------NELAEFQNEFADISKEEQV 1013

  Fly   506 QRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELV--DYYSNNK---GEVCSS 565
            :|...::.|.:|||||.|||||:|.|...:.:|.:|..||.||..::  :|.:.|.   |..||.
Mosquito  1014 KRLHEMLGPHMLRRLKADVLKNMPTKSEFIVRVELSPLQKKYYKYILTRNYEALNPKGGGGACSL 1078

  Fly   566 SERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVY 630
                 |.|||::::..|||                               |:|  .|...:.|:.
Mosquito  1079 -----INIMMDLKKCCNHP-------------------------------YLF--AAAAEEAQLG 1105

  Fly   631 QMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGF 695
            ...|    |:::   :|...:||.:.|:.:|..||::|||||:|||.|.||||:|::|....:.:
Mosquito  1106 PGGN----YELQ---SLTKAAGKLVLLEKMLRLLKSQGHRVLIFSQMTKMLDILEDFLEGLGYKY 1163

  Fly   696 CRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAED 759
            .|:||....::||:.|..||...: .|.|||||:|||:||||..|||.:|:|.|:||:||.||..
Mosquito  1164 ERIDGGITGSIRQEAIDRFNAPGAPQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFS 1228

  Fly   760 RCHRMGQQRPVTIYRLISESTIEEGILMAAEEKL------------------------------- 793
            |.||:||...|.|||.::.:::||.:...|:.|:
Mosquito  1229 RAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGTNFTKQELDDILRFGT 1293

  Fly   794 -KLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLN 832
             :|.|:...:|:...::.:.|.:||..:   :|..||:.|
Mosquito  1294 EELFKEDGKDEEAIHYDDKAVAELLDRS---NKGVEEKEN 1330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	8/43 (19%)
		HepA	<276..795	CDD:440319	191/583 (33%)
Mi-2	XP_061510532.1	None