DRSC/TRiP Functional Genomics Resources

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Protein Alignment mtDNA-helicase and TWNK

DIOPT Version :9

Sequence 1:NP_609318.1 Gene:mtDNA-helicase / 34307 FlyBaseID:FBgn0032154 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_068602.2 Gene:TWNK / 56652 HGNCID:1160 Length:684 Species:Homo sapiens


Alignment Length:630 Identity:250/630 - (39%)
Similarity:360/630 - (57%) Gaps:53/630 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 RKNYATQVVSGLEECSLDPKEYVDFKRQLRQLNLPHKDGHTCLQLECRLCDRNRQPVTNAQKGTD 86
            |:.|..:.:..|:...| |....:.::.||...:|.:|||:||:......:.::   ...|.|..
Human    37 RRRYRKETLQALDMPVL-PVTATEIRQYLRGHGIPFQDGHSCLRALSPFAESSQ---LKGQTGVT 97

  Fly    87 HGLLAYVNKRTGAFICPNC-------DVKTSL----TSALLSYQLPKPVGYKQPLQRQPVYESRF 140
            .....:::|.||.|:|...       |.:.|:    ..|...:.|.|...::...:.:.::....
Human    98 TSFSLFIDKTTGHFLCMTSLAEGSWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAI 162

  Fly   141 PHLAVVTPE----ACAALGIKGLKEDQLNAIGAQW-EPQQQLLH--FK-----LRNAAQVEV--- 190
            |...:...|    |....|:..:.:|.|.....:: .|.:.|:.  |.     ||....:|.   
Human   163 PLWELPDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQ 227

  Fly   191 GEKVLYLGDRREEIFQSSSSSGLLIHG----AMNKTKAVLVSNLIDFIVLATQNIETHC-VVCLP 250
            |:.|.|     ||......|:...:.|    :....:.||.|..:|.:.|   |..|.. .:.||
Human   228 GDGVSY-----EETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLAL---NQSTGLPTLTLP 284

  Fly   251 YELKTLPQECLPALERFKELIFWLHYDASHSWDAARAFALKLDERRCLLIRPTETEPAPHLALRR 315
            .....||...||.||:|:.::|||. |...||:||:.||.||:.:||.|:||.:.:|.|..||..
Human   285 RGTTCLPPALLPYLEQFRRIVFWLG-DDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNG 348

  Fly   316 RLNLRHILAKATPVQHKAITTFGAMRNDILSELQNIEKVNGVKWKRFPVLNKLLKGHRRGELTIL 380
            ..||..||..|.|..||:|.:|..:|.::|.||.|:|:..|::|.|||.||::|||||:||||:.
Human   349 GFNLSRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVF 413

  Fly   381 TGPTGSGKTTFMSEYSLDLAMQGVNTLWGSFEIRNTRLAATLLRQYVGYPLDDRLHEFNHWAAEF 445
            |||||||||||:|||:|||..||||||||||||.|.|||..:|.|:....|:|:|.:::|||..|
Human   414 TGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRF 478

  Fly   446 ERLPLYFMTFHGQQPLKPVLEAIEHASYVHDVMHVIIDNLQFMMGVSTFRGDKFFEQDSIIAAFR 510
            |.||||||||||||.::.|::.::||.||:|:.||||||||||||......|:...||.||..||
Human   479 EDLPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFR 543

  Fly   511 SFATKHNVHVTLVMHPRKERQEDELTTSSVFGTAKATQEADNVLIIQDKRLTSVRGKKYLQIAKN 575
            .|||.:|.|||||:|||||..:.||.|:|:||:|||:||||||||:||::|.:..||:|||::||
Human   544 KFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKN 608

  Fly   576 RYSGDLGIMPLEFDKDGLSYSTQIQNAKRKRE---------KTPS 611
            |:.||:|:.||||:|:.|::|...:|..|.::         |.||
Human   609 RFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPS 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mtDNA-helicaseNP_609318.1 GP4d_helicase 342..598 CDD:238542 153/255 (60%)
TWNKNP_068602.2 TOPRIM_primases 259..335 CDD:173779 31/79 (39%)
GP4d_helicase 374..632 CDD:238542 154/257 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..684 4/17 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158697
Domainoid 1 1.000 240 1.000 Domainoid score I2277
eggNOG 1 0.900 - - E1_KOG2373
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11052
Inparanoid 1 1.050 424 1.000 Inparanoid score I1770
Isobase 1 0.950 - 0 Normalized mean entropy S5213
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D115878at33208
OrthoFinder 1 1.000 - - FOG0006310
OrthoInspector 1 1.000 - - oto89955
orthoMCL 1 0.900 - - OOG6_103182
Panther 1 1.100 - - LDO PTHR12873
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4002
SonicParanoid 1 1.000 - - X5258
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.740

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