Protein Alignment mtDNA-helicase and Twnk

DIOPT Version :9

• Sequence 1: NP_609318.1
• Gene: mtDNA-helicase / 34307
• FlyBaseID: FBgn0032154
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: XP_008758651.1
• Gene: Twnk / 309441
• RGDID: 1307884
• Length: 686
• Species: Rattus norvegicus
• Alignment Length: 696
• Identity: 258/696 - (37%)
• Similarity: 368/696 - (52%)
• Gaps: 137/696 - (19%)

  Fly     1 MRRAGLIKPLLRINNEKQRVW---------------RKNYATQVVSGLEECSLDPKEYVDFKRQL 50
            :|||..::.||.:..|    |               |:.|..:.:..| |..:.|....:.::.|
  Rat     5 LRRAYPLRILLPLRGE----WMGRRGLPRSLAPGPPRRRYRKEALPAL-EVPVSPVTTTEIRQYL 64

  Fly    51 RQLNLPHKDGHTCLQLECRLCDRNRQP--------VTNAQKGTDHGLLAYVNKRTGAFICPNCDV 107
            |...:|.:|||:||          |.|        :.|.:|........:::|.||.|:|
  Rat    65 RAHGIPFQDGHSCL----------RAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLC----- 114

  Fly   108 KTSLTSALLSYQLPKPVGYKQPLQRQPVYESRFPHLAVVTPEACAALGIKGLKEDQLNAIGAQWE 172
            .|||..           |..:.||..  .|.|.                .|.||..|...|.:.|
  Rat   115 MTSLAE-----------GSWEDLQAS--VEGRG----------------DGAKEGILLGEGPEAE 150

  Fly   173 PQQQLLH--------FKLRNAAQVEVGE----------------KVLYLGDRREEIFQ--SSSSS 211
            .::::|.        ::|.:..:.::..                .|.||...|..:|.  :..||
  Rat   151 DREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLRRFNVRYLRSTRSLVFPWFTPGSS 215

  Fly   212 GLL------IHGAMN---------------------------KTKAVLVSNLIDFIVLA-TQNIE 242
            ||.      :.|..|                           .|:.||.|..:|.:.|: :..:.
  Rat   216 GLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGRRDTEVVLTSRELDSLALSQSTGLP 280

  Fly   243 THCVVCLPYELKTLPQECLPALERFKELIFWLHYDASHSWDAARAFALKLDERRCLLIRPTETEP 307
            |   :.||.....||...||.||:|:.::|||. |...||:||:.||.||:.:||.|:||...:|
  Rat   281 T---LSLPRGTVCLPPALLPYLEQFRRIVFWLG-DDLRSWEAAKLFARKLNPKRCSLVRPGNQQP 341

  Fly   308 APHLALRRRLNLRHILAKATPVQHKAITTFGAMRNDILSELQNIEKVNGVKWKRFPVLNKLLKGH 372
            .|..||.:.|:|..||..|.|..||:|.:|..:|.::|.||.|:::..||:|.|||.||:|||||
  Rat   342 RPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVDQAAGVRWSRFPDLNRLLKGH 406

  Fly   373 RRGELTILTGPTGSGKTTFMSEYSLDLAMQGVNTLWGSFEIRNTRLAATLLRQYVGYPLDDRLHE 437
            |:||||:.|||||||||||:|||:|||..||||||||||||.|.|||..:|.|:....|:::|.:
  Rat   407 RKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDK 471

  Fly   438 FNHWAAEFERLPLYFMTFHGQQPLKPVLEAIEHASYVHDVMHVIIDNLQFMMGVSTFRGDKFFEQ 502
            :..||..||.||||||||||||.::.|::.::||.||:||.||:|||||||||......|:...|
  Rat   472 YEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQ 536

  Fly   503 DSIIAAFRSFATKHNVHVTLVMHPRKERQEDELTTSSVFGTAKATQEADNVLIIQDKRLTSVRGK 567
            |.|:.|||.|||.::.|||||:|||||..:.||.|:|:||:|||:||||||||:||::|.:..||
  Rat   537 DYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK 601

  Fly   568 KYLQIAKNRYSGDLGIMPLEFDKDGLSYSTQIQNAKRKREKTPSEN 613
            :|||::|||:.||:|:.||||:|..|::|.. ..:|.:.:|...:|
  Rat   602 RYLQVSKNRFDGDVGVFPLEFNKSSLTFSIP-PKSKARLKKIKDDN 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtDNA-helicase	NP_609318.1	GP4d_helicase	342..598	CDD:238542	151/255 (59%)
Twnk	XP_008758651.1	TOPRIM_primases	260..336	CDD:173779	30/79 (38%)
		GP4d_helicase	375..633	CDD:238542	152/258 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352706
Domainoid	1	1.000	236	1.000	Domainoid score	I2268
eggNOG	1	0.900	-	-		E1_KOG2373
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11052
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1738
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115878at33208
OrthoFinder	1	1.000	-	-		FOG0006310
OrthoInspector	1	1.000	-	-		oto97072
orthoMCL	1	0.900	-	-		OOG6_103182
Panther	1	1.100	-	-	LDO	PTHR12873
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760