DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtDNA-helicase and Twnk

DIOPT Version :9

Sequence 1:	NP_609318.1	Gene:	mtDNA-helicase / 34307	FlyBaseID:	FBgn0032154	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_722491.2	Gene:	Twnk / 226153	MGIID:	2137410	Length:	685	Species:	Mus musculus

Alignment Length:	668	Identity:	252/668 - (37%)
Similarity:	373/668 - (55%)	Gaps:	81/668 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRRAGLIKPLLRINNEKQRVW---------------RKNYATQVVSGLEECSLDPKEYVDFKRQL 50
            :|||..::.||.:..|    |               |:.|..:.:..| |..:.|....:.::.|
Mouse     5 LRRAYPLRILLPLRGE----WVGRRGLPRSLAPGPPRRRYRKEALPAL-EMPVSPVTTTEIRQYL 64

  Fly    51 RQLNLPHKDGHTCLQLECRLCDRNRQP--------VTNAQKGTDHGLLAYVNKRTGAFICPNC-- 105
            |...:|.:|||:||          |.|        :.|.:|........:::|.||.|:|...
Mouse    65 RAHGIPFQDGHSCL----------RAPSPFVVSSDIKNEKKDAPTSFCLFIDKTTGHFLCMTSLA 119

  Fly   106 -----DVKTSL-------TSALLSYQLPKPVGYKQPLQRQPVYESRFPHLAVVTPE----ACAAL 154
                 |::.|:       ...:|..:.|:....::.|:   ::....|...:..||    |....
Mouse   120 EGSWEDLQASVEGRGDGAKEGVLLREGPEAEVREEVLR---IWNRAIPLWELPDPEEAQLARVMF 181

  Fly   155 GIKGLKEDQLNAIGAQWEPQQQLLHF-------------KLRNAAQVEVGEKVLYLGDRREEIFQ 206
            |:..:.:|.|.....::....:.|.|             ||..|...|.|.:.:.....|..::.
Mouse   182 GLTKVTDDTLRRFSVRYLRSARSLVFPWFTPGSSGLRGLKLLGAEGQENGVQYVETTIPRPGVYH 246

  Fly   207 SSSSSGLLIHGAMNKTKAVLVSNLIDFIVLA-TQNIETHCVVCLPYELKTLPQECLPALERFKEL 270
            :.....|:   :...|:.|:.|..:|.:.|: :..:.|   :.||.....||...||.||:|:.:
Mouse   247 NLFGLPLI---SRRDTEVVVTSRELDSLALSQSTGLPT---LSLPRGTVCLPPALLPYLEQFRRI 305

  Fly   271 IFWLHYDASHSWDAARAFALKLDERRCLLIRPTETEPAPHLALRRRLNLRHILAKATPVQHKAIT 335
            :|||. |...||:||:.||.||:.:||.|:||...:|.|..||.:.|:|..||..|.|..||:|.
Mouse   306 VFWLG-DDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIV 369

  Fly   336 TFGAMRNDILSELQNIEKVNGVKWKRFPVLNKLLKGHRRGELTILTGPTGSGKTTFMSEYSLDLA 400
            :|..:|.::|.||.|:|:..||:|.|||.||:||||||:||||:.|||||||||||:|||:|||.
Mouse   370 SFRQLREEVLGELSNVEQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLC 434

  Fly   401 MQGVNTLWGSFEIRNTRLAATLLRQYVGYPLDDRLHEFNHWAAEFERLPLYFMTFHGQQPLKPVL 465
            .||||||||||||.|.|||..:|.|:....|:::|.::..||..||.||||||||||||.::.|:
Mouse   435 TQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVI 499

  Fly   466 EAIEHASYVHDVMHVIIDNLQFMMGVSTFRGDKFFEQDSIIAAFRSFATKHNVHVTLVMHPRKER 530
            :.::||.||:||.||:|||||||||......|:...||.|:.|||.|||.::.|||||:|||||.
Mouse   500 DTMQHAVYVYDVCHVVIDNLQFMMGHEQLSSDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKED 564

  Fly   531 QEDELTTSSVFGTAKATQEADNVLIIQDKRLTSVRGKKYLQIAKNRYSGDLGIMPLEFDKDGLSY 595
            .:.||.|:|:||:|||:||||||||:||::|.:..||:|||::|||:.||:|:.||||:|:.|::
Mouse   565 DDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTF 629

  Fly   596 STQIQNAKRKREKTPSEN 613
            |.. ..:|.:.:|...:|
Mouse   630 SIP-PKSKARLKKIKDDN 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtDNA-helicase	NP_609318.1	GP4d_helicase	342..598	CDD:238542	152/255 (60%)
Twnk	NP_722491.2	TOPRIM_primases	260..336	CDD:173779	29/79 (37%)
		DnaB	<366..624	CDD:223382	153/257 (60%)
		GP4d_helicase	375..633	CDD:238542	153/258 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..685		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849095
Domainoid	1	1.000	237	1.000	Domainoid score	I2322
eggNOG	1	0.900	-	-		E1_KOG2373
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11052
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1758
Isobase	1	0.950	-	0	Normalized mean entropy	S5213
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006310
OrthoInspector	1	1.000	-	-		oto93530
orthoMCL	1	0.900	-	-		OOG6_103182
Panther	1	1.100	-	-	LDO	PTHR12873
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4002
SonicParanoid	1	1.000	-	-		X5258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730