Protein Alignment mtDNA-helicase and twnk-1

DIOPT Version :9

• Sequence 1: NP_609318.1
• Gene: mtDNA-helicase / 34307
• FlyBaseID: FBgn0032154
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001368724.1
• Gene: twnk-1 / 180845
• WormBaseID: WBGene00018514
• Length: 604
• Species: Caenorhabditis elegans
• Alignment Length: 488
• Identity: 155/488 - (31%)
• Similarity: 233/488 - (47%)
• Gaps: 76/488 - (15%)

  Fly   154 LGIKGLKEDQLNAIGAQWEP----QQQLLHFKLR---NAAQVEVGEKVL-YLGDRRE-------- 202
            |||:.:..:.|.....:.:.    |..:|..:.|   :..::.:|.|:: .:|||.|
 Worm   105 LGIENISFETLARFNVRVQTDTYGQPAILFPRYRGMTSRLRIPMGLKLIRKVGDRMEKENYPLPD 169

  Fly   203 EIFQSSSSSGLL-IHGA-MNKTKAVLVSNLIDFIVL--ATQNIETHCVVCLPYELKTLPQECLPA 263
            |.......:|:. :|.| ::....|:.:|..|.:.:  ||:.:    |..||:. :.|....||.
 Worm   170 ETSVRQKFNGVFGLHMATLSDRSVVITTNERDALAIYEATKAL----VFALPHG-EILDPLVLPY 229

  Fly   264 LERFKELIFWL---HYDASHSWDAARAFALKLDERRCLLI----RPTE-TEPAPHLALRRRLNLR 320
            ||.|.::..|.   |...:..|.:|      |:..:|||:    ||.| .....|..:|.  :|.
 Worm   230 LEEFDKIYLWFPVQHVSYAKDWGSA------LNTLKCLLVKNEERPIELVRNGDHRLIRN--SLS 286

  Fly   321 HILAKATPVQHKAITTFGAMRNDILSELQN-IEKVNGV-KWKRFPVLNKLLKGHRRGELTILTGP 383
            :.:.:......:::|... ||..|.|:|.| ..:|.|. :||||.||||.|.|.|.||:|:|||.
 Worm   287 NSVVRMRERGFRSMTDLD-MREGIRSDLLNSTNRVVGFGQWKRFAVLNKYLGGLRPGEMTVLTGG 350

  Fly   384 TGSGKTTFMSEYSLDLAMQGVNTLWGSFEIRNTRLAATLLRQYVG------------------YP 430
            ||:|||||:.||||||..|||.||:.|||:...::...:|.||.|                  .|
 Worm   351 TGNGKTTFLCEYSLDLFTQGVRTLFCSFEMPEKKILHWMLVQYAGPSHLRSLARTNSYKNGIKLP 415

  Fly   431 LD--DRLHEFNHWAAEFERLPLYFMTFHGQQPLKPVLEAIEHASYVH----DVMHVIIDNLQF-- 487
            |.  :..:..|.|...|||..........::.::..:..|..|..:|    .:.||:||||||
 Worm   416 LHRVEYSNSINSWLDRFERSSSALTMLDSEEFMEKSINEIVRAIRIHVENSGIQHVVIDNLQFLI 480

  Fly   488 ---MMGVSTFRG-DKFFEQDSIIAAFRSFATKHNVHVTLVMHPRKERQEDELTTSSVFGTAKATQ 548
               ||......| |:|..||..:...|..||::.:|:|:|:||||...:.|:......|:|:.||
 Worm   481 NQGMMADEKSSGLDRFHLQDRFVGYMRQLATQNQIHITMVVHPRKTDGDTEIDVQHFGGSARVTQ 545

  Fly   549 EADNVLIIQDKRLTSVRGK--KYLQIAKNRYSG 579
            |||||:.||.||....|.|  |:|.|.||||.|
 Worm   546 EADNVIAIQRKRDDRDRSKFRKFLYILKNRYYG 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtDNA-helicase	NP_609318.1	GP4d_helicase	342..598	CDD:238542	107/272 (39%)
twnk-1	NP_001368724.1	Twinkle_C	299..598	CDD:410867	110/281 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166264
Domainoid	1	1.000	118	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_KOG2373
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11052
Inparanoid	1	1.050	173	1.000	Inparanoid score	I2727
Isobase	1	0.950	-	0	Normalized mean entropy	S5213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115878at33208
OrthoFinder	1	1.000	-	-		FOG0006310
OrthoInspector	1	1.000	-	-		oto18706
orthoMCL	1	0.900	-	-		OOG6_103182
Panther	1	1.100	-	-	LDO	PTHR12873
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4002
SonicParanoid	1	1.000	-	-		X5258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740