Protein Alignment mtDNA-helicase and twnk

DIOPT Version :9

• Sequence 1: NP_609318.1
• Gene: mtDNA-helicase / 34307
• FlyBaseID: FBgn0032154
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: XP_002938766.1
• Gene: twnk / 100491229
• XenbaseID: XB-GENE-978896
• Length: 677
• Species: Xenopus tropicalis
• Alignment Length: 647
• Identity: 249/647 - (38%)
• Similarity: 368/647 - (56%)
• Gaps: 74/647 - (11%)

  Fly    18 QRVWRKNYATQVVSGLEECSLDPKEYVDFKRQLRQLNLPHKDGHTCLQLECRLCDRNRQPVTNAQ 82
            :|.::|...| |:.|    ||.|....:.::.||..|:..:||::||.:.        .|.|
 Frog    52 RRHFKKGLLT-VLDG----SLQPVTVTEIRQYLRSKNVSFRDGYSCLHVP--------SPFT--- 100

  Fly    83 KGTDHGLLAYVNKRTGAFICPNCDVKTSLTSALLSYQLPKPVG--YKQP---------------- 129
              .:.....:::|.||.|:|....::.|......|.:|....|  |..|
 Frog   101 --PERDTCLFIDKTTGRFLCKATLLEGSWEDFQDSMELLHKEGCSYLSPDILAGYLAESDSDSAE 163

  Fly   130 -----LQRQPVYESR--FPHLAVVTPEACAAL-GIKGLKEDQLNAIGAQ-WEPQQQLLHFKLRNA 185
                 .:.:.:::..  |..|.....|...|: .|..:....|...|.: ::|.:.|: |...|.
 Frog   164 AQLNDSEVRRIWDKAVWFSDLGEEEAELIKAMYNITKIANSTLKKFGVKCFQPTKSLV-FPWYNP 227

  Fly   186 AQVEV-GEKVLYLGDRREEIFQSSSS----------SGLLIHGAMNKTKAVLVSNLIDFIVLATQ 239
            ....: |.|:|.....:::|..:.::          .||.:.| ..:|:.|:.:..:|.:.:...
 Frog   228 RDFSLNGLKLLSAESHKQKIHYTETTFPRPARYYNLFGLCVSG-KKETEVVITNGEVDCLAIHQS 291

  Fly   240 NIETHCVVCLPYELKTLPQECLPALERFKELIFWLHYDASHSWDAARAFALKLDERRCLLIRPTE 304
            ...|  .:.||.....||...||.||:||.:|.||. |...||:|::.||.||:.:||.||||.:
 Frog   292 TGVT--TLALPRGASCLPPVLLPYLEQFKRIILWLG-DDLRSWEASKLFARKLNMKRCSLIRPGD 353

  Fly   305 TEPAPHLALRRRLNLRHILAKATPVQHKAITTFGAMRNDILSELQNIEKVNGVKWKRFPVLNKLL 369
            .:|:|..||...||:..||..:.|..||:|.:|..:|.::..:|:|.::|.||||.|||.|||||
 Frog   354 KQPSPLQALNDGLNITKILKASLPASHKSIISFRQLREEVFGQLENADQVAGVKWARFPELNKLL 418

  Fly   370 KGHRRGELTILTGPTGSGKTTFMSEYSLDLAMQGVNTLWGSFEIRNTRLAATLLRQYVGYPLDDR 434
            ||||:||||:.|||||||||||:|||:|||.:||||||||||||.|.|||..:|.|:....|:::
 Frog   419 KGHRKGELTVFTGPTGSGKTTFISEYALDLCIQGVNTLWGSFEINNVRLAKIMLTQFALQRLEEQ 483

  Fly   435 LHEFNHWAAEFERLPLYFMTFHGQQPLKPVLEAIEHASYVHDVMHVIIDNLQFMMGVSTFRGDKF 499
            |.:::.||..||.||||||||||||.:|.|::.::||.|::|:.||||||||||||......|:|
 Frog   484 LDKYDEWADRFEDLPLYFMTFHGQQNIKSVIDTMQHAVYMYDITHVIIDNLQFMMGQENLYTDRF 548

  Fly   500 FEQDSIIAAFRSFATKHNVHVTLVMHPRKERQEDELTTSSVFGTAKATQEADNVLIIQDKRLTSV 564
            ..||.::.|||.|||.:|.|||:|:|||||..:.||.|||:||:|||:||||||||:||::|.:.
 Frog   549 AAQDYMVGAFRKFATDNNCHVTVVIHPRKEDDDKELQTSSIFGSAKASQEADNVLILQDRKLVTG 613

  Fly   565 RGKKYLQIAKNRYSGDLGIMPLEFDKDGLSYSTQIQNAKRKR-------------EKTPSEN 613
            .||::||:||||:.||:|:..|||:|..||:::.....|.|:             |:||::|
 Frog   614 PGKRHLQVAKNRFDGDVGVFSLEFNKPCLSFASTKGKQKVKKLNKDAETPSSKASEETPAKN 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtDNA-helicase	NP_609318.1	GP4d_helicase	342..598	CDD:238542	152/255 (60%)
twnk	XP_002938766.1	TOPRIM_primases	275..351	CDD:173779	28/78 (36%)
		GP4d_helicase	390..639	CDD:238542	150/248 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I2198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11052
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1822
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115878at33208
OrthoFinder	1	1.000	-	-		FOG0006310
OrthoInspector	1	1.000	-	-		oto103763
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4002
SonicParanoid	1	1.000	-	-		X5258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.000