Protein Alignment nAChRalpha6 and HTR3B

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_006019.1
• Gene: HTR3B / 9177
• HGNCID: 5298
• Length: 441
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 118/517 - (22%)
• Similarity: 206/517 - (39%)
• Gaps: 115/517 - (22%)

  Fly    14 LLIFLAIIKESCQGPHEKRLLN---HLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQI 75
            :|:...|:......|.:..|.:   .||..|:...|||.|.::...|...|.:..|:|||.:|||
Human    13 ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQI 77

  Fly    76 LTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSAD-EGF-DGTYHTNIVVKH 138
            |.|:.|....|||..|.||.:.:..::::.:..:.:|.||:::....| |.: |..|   :.|..
Human    78 LKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY---VYVNS 139

  Fly   139 NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL--NSED-GGDLSDFITN 200
            :|:.....|....|.|.::...||||.|:|.:.|.|..:....:||..  :.|| ..|...|:.:
Human   140 SGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLND 204

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            .||.||::....:  :.......:..|.|.:.:||..|.|..:|::|.:.:..:.|..|.|||:.
Human   205 SEWELLSVSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNC 267

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            ..::....::|:..|||...::..:|.:      :|.|                       ||:|
Human   268 RARIVFKTSVLVGYTVFRVNMSNQVPRS------VGST-----------------------PLIG 303

  Fly   331 TYFN-CIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTIL 394
            .:|. |:.|:|.|.....|:|...|.......|.|      ||     .||.
Human   304 HFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP------FL-----CLRG------------- 344

  Fly   395 LSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSAS-----FGRPTTVEEHHTAIG 454
                                   |.|.|.......:|.|:.:.:|     ..:|.|::|
Human   345 -----------------------DTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKE------ 380

  Fly   455 CNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFT--LFTI-IATVTV 513
                    :..:||.|:..::..|...:...:|   .:::.||..::|.  ||.: |.|:|:
Human   381 --------VWSQLQSISNYLQTQDQTDQQEAEW---LVLLSRFDRLLFQSYLFMLGIYTITL 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	118/517 (23%)
		LGIC_ECD_nAChR	55..236	CDD:349798	51/185 (28%)
HTR3B	NP_006019.1	LIC	8..435	CDD:273305	118/517 (23%)
		Neur_chan_LBD	33..239	CDD:280998	59/210 (28%)
		Neur_chan_memb	246..>328	CDD:280999	24/110 (22%)
		HA-stretch	381..413		6/34 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910