Protein Alignment nAChRalpha6 and CHRFAM7A

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 183/413 - (44%)
• Similarity: 241/413 - (58%)
• Gaps: 49/413 - (11%)

  Fly   122 ADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL 186
            |||.||.|:|||::|..:|.|.|:|||||||:|.||:.|||||.|||::|||||:|.|..|||.:
Human    28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM 92

  Fly   187 NSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLI 251
            ..   .|:|.:|.||||.|:.:|||::...|.||.|||.|:|||:.:|||||||..||::|||||
Human    93 QE---ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 154

  Fly   252 SSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316
            |::|||.|.||.|||||::||:|:|||||||:.||||.||.|||:||||
Human   155 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI---------------- 203

  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM 381
                         ..||...|.:|..|||:||:||.|||...|..:||.|.:.:.|.|..|.|||
Human   204 -------------AQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRM 255

  Fly   382 GRPGRKITRKTILLSNRMKELELKERSS----KSLLANVLDIDDDFR-----HTISGSQTAIGSS 437
            .|||....|.......|...|...|.|:    .:...|:|.|  .||     |.:....:.:...
Human   256 KRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI--GFRGLDGVHCVPTPDSGVVCG 318

  Fly   438 ASFGRPTTVEEHHTAIGC----NHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC 498
            .....||  .:.|...|.    ...||..||:|:::|..|.|..|:...:..:|||||.||||.|
Human   319 RMACSPT--HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381

  Fly   499 LIVFTLFTIIATVTVLLSAPHII 521
            |:.|::||||.|:.:|:|||:.:
Human   382 LMAFSVFTIICTIGILMSAPNFV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	180/407 (44%)
		LGIC_ECD_nAChR	55..236	CDD:349798	63/113 (56%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
CHRFAM7A	NP_647536.1	LIC	<28..400	CDD:455710	180/407 (44%)