Protein Alignment nAChRalpha6 and CHRFAM7A

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 183/413 - (44%)
• Similarity: 241/413 - (58%)
• Gaps: 49/413 - (11%)

  Fly   122 ADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL 186
            |||.||.|:|||::|..:|.|.|:|||||||:|.||:.|||||.|||::|||||:|.|..|||.:
Human    28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM 92

  Fly   187 NSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLI 251
            ..   .|:|.:|.||||.|:.:|||::...|.||.|||.|:|||:.:|||||||..||::|||||
Human    93 QE---ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 154

  Fly   252 SSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316
            |::|||.|.||.|||||::||:|:|||||||:.||||.||.|||:||||
Human   155 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI---------------- 203

  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM 381
                         ..||...|.:|..|||:||:||.|||...|..:||.|.:.:.|.|..|.|||
Human   204 -------------AQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRM 255

  Fly   382 GRPGRKITRKTILLSNRMKELELKERSS----KSLLANVLDIDDDFR-----HTISGSQTAIGSS 437
            .|||....|.......|...|...|.|:    .:...|:|.|  .||     |.:....:.:...
Human   256 KRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYI--GFRGLDGVHCVPTPDSGVVCG 318

  Fly   438 ASFGRPTTVEEHHTAIGC----NHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC 498
            .....||  .:.|...|.    ...||..||:|:::|..|.|..|:...:..:|||||.||||.|
Human   319 RMACSPT--HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381

  Fly   499 LIVFTLFTIIATVTVLLSAPHII 521
            |:.|::||||.|:.:|:|||:.:
Human   382 LMAFSVFTIICTIGILMSAPNFV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	180/407 (44%)
		LGIC_ECD_nAChR	55..236	CDD:349798	63/113 (56%)
CHRFAM7A	NP_647536.1	Neur_chan_LBD	<28..400	CDD:332142	180/407 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3411
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm8451
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820