Protein Alignment nAChRalpha6 and CHRNA6

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 199/531 - (37%)
• Similarity: 280/531 - (52%)
• Gaps: 93/531 - (17%)

  Fly    14 LLIFLAIIKESCQG-PHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILT 77
            |.:|....| .|.| ..|:||.:.|.|.||...|||.|.|:|:.|.|.:.:.|:.:|||.|||:.
Human    18 LCVFTPFFK-GCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIME 81

  Fly    78 TNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSC 142
            ||.||...||||.|||:..||.|::.||:..:|:||||:::||:|...|.....|..::|:||..
Human    82 TNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMI 146

  Fly   143 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLD-LVLNSEDGGDLSDFITNGEWYLL 206
            .:.||.||||:|.:|||:||||.|:|.:||||||||..::| |::.|:  .|::||..|.||.::
Human   147 TWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEII 209

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            ...|.|:.|.|.||.|.|.|||::..|||..::|..|||:||:.||.:.:|.|.||.|.|||:||
Human   210 DASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTL 274

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            .:::||||||||.::.|::|:||..|||:|..:|.:
Human   275 CISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFT----------------------------- 310

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKE 401
            |..|..|:|:||.|||.|:||...|.||.|:|:|||:.||.:|.|..|..| ||.|   .:....
Human   311 MIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDK-TRGT---GSDAVP 371

  Fly   402 LELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHL---- 462
            ..|..|.:|                        |..||.|.|..::|   ...| ||...|
Human   372 RGLARRPAK------------------------GKLASHGEPRHLKE---CFHC-HKSNELATSK 408

  Fly   463 -----------------------ILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTL 504
                                   ::..:|||...|:..::..|:..|||:.||||||..|.||.:
Human   409 RRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473

  Fly   505 FTIIATVTVLL 515
            ..:..|..:.|
Human   474 VCVFGTAGLFL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	199/531 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	84/181 (46%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
CHRNA6	NP_004189.1	LIC	34..484	CDD:455710	193/512 (38%)
		LGIC_ECD	34..240	CDD:475126	98/207 (47%)