DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and CHRNA6

DIOPT Version :9

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_004189.1 Gene:CHRNA6 / 8973 HGNCID:15963 Length:494 Species:Homo sapiens


Alignment Length:531 Identity:199/531 - (37%)
Similarity:280/531 - (52%) Gaps:93/531 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LLIFLAIIKESCQG-PHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILT 77
            |.:|....| .|.| ..|:||.:.|.|.||...|||.|.|:|:.|.|.:.:.|:.:|||.|||:.
Human    18 LCVFTPFFK-GCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIME 81

  Fly    78 TNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSC 142
            ||.||...||||.|||:..||.|::.||:..:|:||||:::||:|...|.....|..::|:||..
Human    82 TNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMI 146

  Fly   143 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLD-LVLNSEDGGDLSDFITNGEWYLL 206
            .:.||.||||:|.:|||:||||.|:|.:||||||||..::| |::.|:  .|::||..|.||.::
Human   147 TWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEII 209

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            ...|.|:.|.|.||.|.|.|||::..|||..::|..|||:||:.||.:.:|.|.||.|.|||:||
Human   210 DASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTL 274

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            .:::||||||||.::.|::|:||..|||:|..:|.:                             
Human   275 CISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFT----------------------------- 310

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKE 401
            |..|..|:|:||.|||.|:||...|.||.|:|:|||:.||.:|.|..|..| ||.|   .:....
Human   311 MIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDK-TRGT---GSDAVP 371

  Fly   402 LELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHL---- 462
            ..|..|.:|                        |..||.|.|..::|   ...| ||...|    
Human   372 RGLARRPAK------------------------GKLASHGEPRHLKE---CFHC-HKSNELATSK 408

  Fly   463 -----------------------ILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTL 504
                                   ::..:|||...|:..::..|:..|||:.||||||..|.||.:
Human   409 RRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473

  Fly   505 FTIIATVTVLL 515
            ..:..|..:.|
Human   474 VCVFGTAGLFL 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 199/531 (37%)
LGIC_ECD_nAChR 55..236 CDD:349798 84/181 (46%)
CHRNA6NP_004189.1 Neur_chan_LBD 34..484 CDD:332142 193/512 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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