Protein Alignment nAChRalpha6 and Chrna6

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_476532.2
• Gene: Chrna6 / 81721
• RGDID: 69281
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 507
• Identity: 196/507 - (38%)
• Similarity: 283/507 - (55%)
• Gaps: 52/507 - (10%)

  Fly    17 FLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAW 81
            |||..|.|.....|::|.:.|.:.||...|||.|.|:|:.|.|.|.:.|:.:|||.|||:.||.|
  Rat    21 FLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLW 85

  Fly    82 LNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVP 146
            |...|.||.|.|:.|||.|::.||:..:.:||||:::||:|...|.....|..::|::|...:.|
  Rat    86 LRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTP 150

  Fly   147 PGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLD-LVLNSEDGGDLSDFITNGEWYLLAMPG 210
            |.||||:|.:|||:||||.|:|.:||||||||..::| |::.|:  .|::||..|.||.::...|
  Rat   151 PAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEIVDASG 213

  Fly   211 KKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTI 275
            .|:.|.|.||.|.|.|||::..|||..::|..|||:||:.||.:.:|.|.||.|.|||:||.:::
  Rat   214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISV 278

  Fly   276 LLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMV 340
            ||||||||.::.|::|:||..:||:|..:|.:                             |..|
  Rat   279 LLSLTVFLLVITETIPSTSLVIPLVGEYLLFT-----------------------------MIFV 314

  Fly   341 ASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITR-------KTILLSNR 398
            ..|:|:||.|||.|:||...|.||.|:|::|||..|.||.|.||..|...       ||  .:.|
  Rat   315 TLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEADGVKDPKT--HTKR 377

  Fly   399 MKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLI 463
            ..:::...|....||       .:.||....|:.|.|...|......|.|:..    :..|:..:
  Rat   378 PAKVKFTHRKEPKLL-------KECRHCHKSSEIAPGKRLSQQPAQWVAENSE----HPPDVEDV 431

  Fly   464 LKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            :..:||||..|:..::..|:..|||:.||||||..|.||.:..:..||.:.|
  Rat   432 IDSVQFITENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	196/507 (39%)
		LGIC_ECD_nAChR	55..236	CDD:349798	82/181 (45%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
Chrna6	NP_476532.2	LIC	34..483	CDD:455710	190/492 (39%)
		LGIC_ECD	34..240	CDD:475126	94/207 (45%)