Protein Alignment nAChRalpha6 and chrna2a

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001035417.1
• Gene: chrna2a / 678575
• ZFINID: ZDB-GENE-040108-2
• Length: 520
• Species: Danio rerio
• Alignment Length: 542
• Identity: 204/542 - (37%)
• Similarity: 286/542 - (52%)
• Gaps: 84/542 - (15%)

  Fly    14 LLIFLA-----IIKESCQGPH-EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            :||.:|     ::.:.....| |.:|.:.|...||...|||.|.|:.:.|||||::.|:||||||
Zfish    15 MLILIADHVQPVLSDGWIHAHAEDKLFHKLFIGYNKWSRPVRNISDVVIVKFGLSIAQLIDVDEK 79

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            ||::|||.||..|||||.||||.:|:..|..:|:....:|.||:::||:||..|..|:.|...:.
Zfish    80 NQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVTHMTKAHLF 144

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202
            |.|...:|||.|:||:|.||:|:||||.|:|:|||||||||..::||. ..|...||.|:..:||
Zfish   145 HTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE-QIEGTVDLKDYWESGE 208

  Fly   203 WYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGE 267
            |.::...|..||..|.||.|.|.|||:...|||..|:|..|||:||:|||.:.:|.|.||.|.||
Zfish   209 WAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGE 273

  Fly   268 KLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTY 332
            |:||.:::||||||||.|:.|.:|:||..:||||..:|.:
Zfish   274 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT------------------------- 313

  Fly   333 FNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP-GRKITRKTILLS 396
                |..|..|:|:||.|||.|||:...|.||.|:.||||..:|..|.|.|| ..|..:||..||
Zfish   314 ----MIFVTLSIVITVFVLNVHHRSPSTHSMPRWVHSVFLDHIPRWLFMRRPEPEKKPKKTANLS 374

  Fly   397 NRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEH------------ 449
                       :|||.......:|.   ......:..||.|.|...|:....|
Zfish   375 -----------TSKSWFQQETGVDG---LVCQDMEFGIGLSTSISSPSATSLHLSDSEPLLQKYE 425

  Fly   450 -----HTAIGCNH--KDLHLI--------------LKELQFITARMRKADDEAELIGDWKFAAMV 493
                 |....|.|  |..:|:              |:.:::|...:|..|::..:..|||:.|||
Zfish   426 LQHLGHVVNLCQHPAKLGNLVSEPGLLFSPCVLRALEGVRYIADHLRAEDEDFSVKEDWKYVAMV 490

  Fly   494 VDRFCLIVFTLFTIIATVTVLL 515
            :||..|.:|.:..::.|:.:.|
Zfish   491 IDRIFLWMFIIVCLLGTIGLFL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	204/542 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	90/180 (50%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:455710	204/542 (38%)
		LGIC_ECD_nAChR_A2	37..243	CDD:349816	101/206 (49%)
		Cys-loop	161..175	CDD:349816	9/13 (69%)