DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and Chrna10

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_006229953.1	Gene:	Chrna10 / 64574	RGDID:	620142	Length:	492	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	168/506 - (33%)
Similarity:	251/506 - (49%)	Gaps:	80/506 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAIIKESCQGPHEK---RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTN 79
            |.|....|.|...:   :|...|.:.|.:..||||:..:.|.|...:||.||||:||:||:||..
  Rat    60 LLIHPPECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLY 124

  Fly    80 AWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLY 144
            .|:..||.|..|.|:...||.:..:||....:|:||:::||.||.....:..||:||:|:|:..:
  Rat   125 LWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRW 189

  Fly   145 VPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMP 209
            ..|.|.:|:|::|::.||||.|.|.:.|||||:.|:||| |........|:||:.|.||.:|.||
  Rat   190 DAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLD-VRPRGTSASLADFVENVEWRVLGMP 253

  Fly   210 GKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVT 274
            .::..:.|.||.|||.|:|||:.:|||...|..||::|||.||.:|.|.|.||.|||||::||||
  Rat   254 ARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVT 318

  Fly   275 ILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFM 339
            :||:||||..::|||||.                              ::::||:|.|:...|.|
  Rat   319 VLLALTVFQLILAESMPP------------------------------AESVPLIGKYYMATMTM 353

  Fly   340 VASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELEL 404
            |..|..||::::|.|:...:.|.:|.|                       .:.:||.:..|.|.:
  Rat   354 VTFSTALTILIMNLHYCGPNAHPVPAW-----------------------ARVLLLGHLAKGLCV 395

  Fly   405 KERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEE---HHTAIGCNHKDLHLILKE 466
            :||...                 .|....:.|:.|...|.....   |.....|:.:.|   |..
  Rat   396 RERGEP-----------------CGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEAL---LHH 440

  Fly   467 LQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            :..|.:..|..........|||..|.|:|||.|.:|....::.::.||:.|
  Rat   441 IASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	167/504 (33%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	78/180 (43%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:273305	164/489 (34%)
		Neur_chan_LBD	77..280	CDD:280998	85/203 (42%)
		Neur_chan_memb	288..482	CDD:280999	72/266 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9885
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920