DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and Htr3b

DIOPT Version :10

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_071525.1 Gene:Htr3b / 58963 RGDID:61820 Length:437 Species:Rattus norvegicus


Alignment Length:286 Identity:81/286 - (28%)
Similarity:139/286 - (48%) Gaps:12/286 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNET 96
            ||...||..|:...|||.|.:|...|...|.:..::|||.:||.|.|:.|....|||..|.||.:
  Rat    30 RLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSS 94

  Fly    97 EYGGVKDLRITPNKLWKPDVLM--YNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            .:..::::.:..:.:|.||:::  :...:...|..|   :.|..:|:.....|....|.|.:...
  Rat    95 LFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPY---VYVNSSGTIRNHKPIQVVSACSLQTY 156

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDL--VLNSED-GGDLSDFITNGEWYLLAMPGKKNTIVYACCP 221
            .||||.|:|.:.|.|..:....:||  :.|.|| ..|...|:.:.||.||::....:  :.....
  Rat   157 AFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYH--IRQSSA 219

  Fly   222 EPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLV 286
            ..:..|.|.:.|||..|.|..:|::|.:.:..:.|..|.|||:...::.....:|:..|||...:
  Rat   220 GDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNM 284

  Fly   287 AESMPTTSDAVPLIGV--TILLSLTV 310
            ::.:|.::....||||  |:.::|.|
  Rat   285 SDEVPRSAGCTSLIGVFFTVCMALLV 310

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:455710 81/286 (28%)
LGIC_ECD_nAChR 55..236 CDD:349798 49/185 (26%)
Cys-loop 154..168 CDD:349798 6/13 (46%)
Htr3bNP_071525.1 LGIC_ECD 25..233 CDD:475126 58/207 (28%)
LGIC_TM_5-HT3 236..432 CDD:349865 21/75 (28%)
TM1 helix 236..260 CDD:349865 6/23 (26%)
TM2 helix 268..289 CDD:349865 4/20 (20%)
TM3 helix 300..322 CDD:349865 4/11 (36%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:O95264 377..409
TM4 helix 407..429 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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