DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha6 and CHRNA10

DIOPT Version :9

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_065135.2 Gene:CHRNA10 / 57053 HGNCID:13800 Length:450 Species:Homo sapiens


Alignment Length:536 Identity:179/536 - (33%)
Similarity:266/536 - (49%) Gaps:121/536 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LSLFVLLIFLAIIKESCQGPHEK---RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |||.:||:||  :...|.|...:   :|...|.:.|.:..||||:..:.|.|...:||.||||:|
Human     8 LSLGLLLLFL--LPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMD 70

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |:||:||...|:..||.|..|||:...|||:..:||..:.:|:||:::||.||....|:..||:|
Human    71 ERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVV 135

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITN 200
            ::|:|:..:..|.|.:|:|::|:..||||.|||.:.|||||:.|:||| |........|:||:.|
Human   136 LRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLD-VRPRGAAASLADFVEN 199

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            .||.:|.||.::..:.|.||.|||.|:|||:.:|||...|..||::||||||.:|.|.|.||.||
Human   200 VEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADS 264

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||::||||:||:||||..|:|||||.                              ::::||:|
Human   265 GEKVSLGVTVLLALTVFQLLLAESMPP------------------------------AESVPLIG 299

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLP---WILRMGRP-GRKITRK 391
            .|:...|.||..|..||::::|.|:....:..:|.|.:::.|..|.   .:...|.| |:     
Human   300 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQ----- 359

  Fly   392 TILLSNRMKELELKERS--------------------SKSLLANVLDIDDDFRHTISGSQTAIGS 436
                 :|..||....:|                    .::||.:|..|.:.||            
Human   360 -----SRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFR------------ 407

  Fly   437 SASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIV 501
                       .|..|..|:.                            |||..|.|:|||.|.:
Human   408 -----------SHRAAQRCHE----------------------------DWKRLARVMDRFFLAI 433

  Fly   502 FTLFTIIATVTVLLSA 517
            |....::.::.||:.|
Human   434 FFSMALVMSLLVLVQA 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 176/532 (33%)
LGIC_ECD_nAChR 55..236 CDD:349798 81/180 (45%)
CHRNA10NP_065135.2 LIC 31..442 CDD:273305 167/502 (33%)
Neur_chan_LBD 32..235 CDD:280998 88/203 (43%)
Neur_chan_memb 243..434 CDD:280999 74/281 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..380 6/34 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 73 1.000 Domainoid score I9252
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D363540at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

Return to query results.
Submit another query.