Protein Alignment nAChRalpha6 and chrnb5b

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_073778294.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 487
• Species: Danio rerio
• Alignment Length: 492
• Identity: 187/492 - (38%)
• Similarity: 281/492 - (57%)
• Gaps: 50/492 - (10%)

  Fly    30 EKRLLNHLLS--TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLR 92
            |:||:|:|||  .||.|.||..|:|:.:.:...::|.|:|.|:|:.||:|||.||...||||.|.
Zfish    25 EERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMTTNCWLTQVWNDYRLM 89

  Fly    93 WNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKID 157
            |:..||.|::.:|:....:|.||:::||:||..::.::::|.||.:||...::||.|:||.|||:
Zfish    90 WDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEVAWLPPAIYKSACKIE 154

  Fly   158 ITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPE 222
            :..||||.|:|.:||.|||||..::||:|.| |.....||..:|||.::::||:||       .:
Zfish   155 VRDFPFDQQNCTLKFRSWTYDHTEIDLILLS-DFASRDDFKPSGEWDIVSLPGRKN-------ED 211

  Fly   223 P----YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFL 283
            |    |:|||:...|||:.|:|..|||:|||||:|:|:|.|.||.|.|||:||.:::||:|||||
Zfish   212 PNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKITLCISVLLALTVFL 276

  Fly   284 NLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTV 348
            .|:::.:|.||.|||||                             |.|....|.:|..|:|.:|
Zfish   277 LLISKIVPPTSLAVPLI-----------------------------GKYLMFTMVLVTFSIVTSV 312

  Fly   349 VVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLL 413
            .|||.|||:...|.||.|:|..||..||..|.|.|||....|      :|.:....:..||...:
Zfish   313 CVLNVHHRSPSTHSMPKWVKYYFLVRLPAFLFMRRPGESNKR------DRFRRKHQQHSSSDVPV 371

  Fly   414 ANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKAD 478
            .:..|..|........|...||..|...:..:......|:.|: .|:...:|.:::|..:|:..|
Zfish   372 KSEADEADSTFFVNEDSANHIGWRAGELQENSELRKRMAVKCS-ADMEEAVKGVRYIADKMKSED 435

  Fly   479 DEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            |:..:|.|||:.|||:||..|.:|.|..:..|:.:.:
Zfish   436 DDEGIIEDWKYVAMVIDRLFLWIFVLVCVAGTIGLFM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	187/492 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	76/184 (41%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrnb5b	XP_073778294.1	None