Protein Alignment nAChRalpha6 and chrna9a

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_021326868.1
• Gene: chrna9a / 568807
• ZFINID: ZDB-GENE-090312-63
• Length: 580
• Species: Danio rerio
• Alignment Length: 611
• Identity: 194/611 - (31%)
• Similarity: 293/611 - (47%)
• Gaps: 139/611 - (22%)

  Fly     9 LSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKN 73
            |.:.:.|:..|:.  |.||...::|||.|:..|:...|||.:..:.|.|...:||.||.|:||:|
Zfish     6 LVIHISLLLHAVF--SAQGRFAQKLLNDLMEGYSNALRPVEDTDKALNVTLQITLSQIKDMDERN 68

  Fly    74 QILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSAD-EGFDGTYHTNIVVK 137
            |:|||..|:...|:|..|.|::.||.|::.:||..|.:|:||:::||:|| |...|...||:|::
Zfish    69 QVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEEDSSGPPDTNVVLR 133

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202
            :||...:..|.|.||:||:|:::||||.|.|.:.||||||:|||:|:.:..| .||||||:.|.|
Zfish   134 YNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVDIAMGME-SGDLSDFVDNVE 197

  Fly   203 WYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGE 267
            |....||..||.|:|.||.:||.|||:|:.::||:.:|.|||::||.|||.:|.|||.||.||||
Zfish   198 WECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPADSGE 262

  Fly   268 KLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTY 332
            |::||||:||:||||..:||||||.                              |:::||:|.|
Zfish   263 KVSLGVTVLLALTVFQLMVAESMPP------------------------------SESVPLIGKY 297

  Fly   333 FNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKIT-----RKT 392
            :...|.|:.:|..||:.::|.|...|:...:|.|.|.:.:.::..|..:...|...|     |..
Zfish   298 YIATMTMITASTSLTIFIMNIHFCGAEAKPVPHWAKVLIIDYMSKIFFVYEVGENCTTPESDRGP 362

  Fly   393 ILLSNRMKELELKERSSKSLLANVLDIDD------------DFRH-------------------- 425
            ....:.:..||......|....: ..:|:            |.||
Zfish   363 FFSEDPLASLERDGYFDKGFYED-CHLDERIRSQFNGYSHRDHRHGNGYHHKNSSYRQHRHEQQR 426

  Fly   426 -TISGSQTAIGSSAS-------FGR------PTTVEE---------------------------- 448
             |.|.|.:.:..|:.       .||      |.|.:|
Zfish   427 RTRSSSNSPVRQSSHHPKYTHFIGRDGSEKLPLTSQEKLKDSEISIPEKINGYTYDQGNGYLNGV 491

  Fly   449 ---HH----------------TAIGC---NHKDLHLILKELQFITARMRKADDEAELIGDWKFAA 491
               |.                |..||   .|:.|   ::.:::|....|:.........:||..|
Zfish   492 GYLHDNGYSKTFGADSYNKTTTGTGCVCGKHQKL---VRNIEYIANCFREQRGHQAKGAEWKKVA 553

  Fly   492 MVVDRFCLIVFTLFTIIATVTVLLSA 517
            .|:|||.:.||.:...:.::.||..|
Zfish   554 KVMDRFFMWVFFIMVFLMSILVLAKA 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	192/607 (32%)
		LGIC_ECD_nAChR	55..236	CDD:349798	86/181 (48%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	94/206 (46%)
		Neur_chan_memb	239..>367	CDD:308533	53/157 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920