Protein Alignment nAChRalpha6 and chrna11

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 612
• Identity: 247/612 - (40%)
• Similarity: 335/612 - (54%)
• Gaps: 139/612 - (22%)

  Fly    12 FVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            |.|....|:|:.|.|||:::.||.:||..||.:||||||:|:||.|...::|.||:|||||||:|
Zfish     7 FTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKNQVL 71

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGS 141
            |||.|||:.|.|:.|:||::||.|||:||.|.:::|.||:|:|||||:.||.|:.:|:||..:|.
Zfish    72 TTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNSSGY 136

  Fly   142 CLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLL 206
            |.|:|||||.|||.:|:.|||||.|.||:||||||:||..|||.:|.   .|:|.::.||||.|:
Zfish   137 CNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE---ADISGYMPNGEWDLV 198

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            .:||.:|.:.|.||.|||.|:||.:.||||||||..||::||||:|||.||.|.||.|||||::|
Zfish   199 GVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPADSGEKISL 263

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            |:|:|||||||:.||||.||.|||::|||                             |.||..|
Zfish   264 GITVLLSLTVFMLLVAEIMPATSDSIPLI-----------------------------GQYFASI 299

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRK-------------- 387
            |.:|..||:.|||||.|||...:...||.|::.|.|||:.|.|||.|||..
Zfish   300 MIIVGMSVIATVVVLQYHHHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLRR 364

  Fly   388 --------------------------------------------------ITRKTILLSNRMKEL 402
                                                              :..:|...:|....|
Zfish   365 CSSGSQSGSLPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLL 429

  Fly   403 -----ELKERSSKSLLANVLDIDDDFRHTISG-------SQTAIGSS------------------ 437
                 .|.|.|..:|||     |...|:::||       |...:|||
Zfish   430 YIGFSSLDEASPPALLA-----DSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTP 489

  Fly   438 --ASFGRPTTVEEHHTAIGCN------HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVV 494
              .:.|.|:||........|:      ...|..||:|::::..|.|..|:...:...|||||.|:
Zfish   490 NLEATGCPSTVSGGGGGCSCSGTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVI 554

  Fly   495 DRFCLIVFTLFTIIATVTVLLSAPHII 521
            ||.||:.|::|.||.|:::|:|||:.:
Zfish   555 DRLCLVAFSVFNIICTISILMSAPNFV 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	244/606 (40%)
		LGIC_ECD_nAChR	55..236	CDD:349798	100/180 (56%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrna11	NP_001038562.1	LIC	2..577	CDD:455710	244/606 (40%)