Protein Alignment nAChRalpha6 and chrna11

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 612
• Identity: 247/612 - (40%)
• Similarity: 335/612 - (54%)
• Gaps: 139/612 - (22%)

  Fly    12 FVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            |.|....|:|:.|.|||:::.||.:||..||.:||||||:|:||.|...::|.||:|||||||:|
Zfish     7 FTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKNQVL 71

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGS 141
            |||.|||:.|.|:.|:||::||.|||:||.|.:::|.||:|:|||||:.||.|:.:|:||..:|.
Zfish    72 TTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNSSGY 136

  Fly   142 CLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLL 206
            |.|:|||||.|||.:|:.|||||.|.||:||||||:||..|||.:|.   .|:|.::.||||.|:
Zfish   137 CNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE---ADISGYMPNGEWDLV 198

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            .:||.:|.:.|.||.|||.|:||.:.||||||||..||::||||:|||.||.|.||.|||||::|
Zfish   199 GVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPADSGEKISL 263

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            |:|:|||||||:.||||.||.|||::|||                             |.||..|
Zfish   264 GITVLLSLTVFMLLVAEIMPATSDSIPLI-----------------------------GQYFASI 299

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRK-------------- 387
            |.:|..||:.|||||.|||...:...||.|::.|.|||:.|.|||.|||..
Zfish   300 MIIVGMSVIATVVVLQYHHHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLRR 364

  Fly   388 --------------------------------------------------ITRKTILLSNRMKEL 402
                                                              :..:|...:|....|
Zfish   365 CSSGSQSGSLPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLL 429

  Fly   403 -----ELKERSSKSLLANVLDIDDDFRHTISG-------SQTAIGSS------------------ 437
                 .|.|.|..:|||     |...|:::||       |...:|||
Zfish   430 YIGFSSLDEASPPALLA-----DSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTP 489

  Fly   438 --ASFGRPTTVEEHHTAIGCN------HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVV 494
              .:.|.|:||........|:      ...|..||:|::::..|.|..|:...:...|||||.|:
Zfish   490 NLEATGCPSTVSGGGGGCSCSGTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVI 554

  Fly   495 DRFCLIVFTLFTIIATVTVLLSAPHII 521
            ||.||:.|::|.||.|:::|:|||:.:
Zfish   555 DRLCLVAFSVFNIICTISILMSAPNFV 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	244/606 (40%)
		LGIC_ECD_nAChR	55..236	CDD:349798	100/180 (56%)
chrna11	NP_001038562.1	LIC	2..577	CDD:273305	244/606 (40%)
		Neur_chan_LBD	25..229	CDD:280998	115/206 (56%)
		Neur_chan_memb	236..573	CDD:280999	114/370 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.840