Protein Alignment nAChRalpha6 and chrnb2

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 566
• Identity: 197/566 - (34%)
• Similarity: 292/566 - (51%)
• Gaps: 100/566 - (17%)

  Fly     9 LSLFVLLIFLAIIKESCQGPHEKRLLNHLLST--YNTLERPVANESEPLEVKFGLTLQQIIDVDE 71
            ::|:.|...|||:|.......|:||:.|||:.  ||.|.||..|.||.:.|:..::|.|:|.|.|
Zfish     2 MALWTLFCILAIVKSGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHE 66

  Fly    72 KNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVV 136
            :.||:|||.||..||.||.|.|:..|:.|:|.:|:....:|.|||::||:||..::.::::|.||
Zfish    67 REQIMTTNVWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVV 131

  Fly   137 KHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNG 201
            .::||..::||.|:||.|||::..||||.|:|.:.|.|||||..::||||.: |...:.||..:|
Zfish   132 SYDGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLRA-DVASMDDFTPSG 195

  Fly   202 EWYLLAMPGKKNTIVYACCPEP----YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP 262
            ||.::|:||::|       ..|    |||||:...|||:.|:|..|||:|||||:|:|:|.|.||
Zfish   196 EWDIIALPGRRN-------ENPSDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLP 253

  Fly   263 PDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIP 327
            .|.|||:||.:::||:|||||.|:::.:|.||..|||:
Zfish   254 SDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLV--------------------------- 291

  Fly   328 LLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKT 392
              |.|....|.:|..|:|.:|.|||.|||:...|.||||:|.|||..||.:|.|.:|.....|:.
Zfish   292 --GKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPPWVKLVFLNKLPALLFMRQPRNSSERQR 354

  Fly   393 ILLSNRMKELELKERSSKSLLANVL---------------------------------------- 417
              |..|.:..|.:|.....|.|.::
Zfish   355 --LRQRRRANEQQEGGRGGLAAGLMAGLGLSGSSSGSKENNEACTCYVNRASVKQFGAELGGGGG 417

  Fly   418 ---------DIDDDFRHTISGSQTAI-GSSASFGR---PTTVEEHHTAIGCNHKDLHLILKELQF 469
                     .|.:..|.|..|....: ||:...|:   ||.:.:...|..|  ......:..::|
Zfish   418 GGGSTDGLNGIREGGRETREGGANPLQGSALPRGKQQPPTVLTQALLAQAC--PGFEEAVDGVRF 480

  Fly   470 ITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            |...|:..||:..:..|||:.|||:||..|.:|....:..|:.:.|
Zfish   481 IANHMKSEDDDRSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	197/564 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	78/184 (42%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:455710	196/562 (35%)
		LGIC_ECD_nAChR_B2	25..228	CDD:349826	92/210 (44%)
		Cys-loop	149..163	CDD:349826	8/13 (62%)