Protein Alignment nAChRalpha6 and chrna4b

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001041528.1
• Gene: chrna4b / 556619
• ZFINID: ZDB-GENE-090505-3
• Length: 627
• Species: Danio rerio
• Alignment Length: 648
• Identity: 214/648 - (33%)
• Similarity: 303/648 - (46%)
• Gaps: 181/648 - (27%)

  Fly    12 FVLLIFLAIIKESCQGP---H-EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            |:|.:.|.:.......|   | |:|||..|...||.|.|||||.|:.:.|.|||::.|:||||||
Zfish     9 FLLCVHLQLAYVFSMSPAHAHAEERLLQSLFINYNKLSRPVANISDVVLVHFGLSIAQLIDVDEK 73

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            ||::|||.|:..|||||.||||..||..|..:||....:|:||:::||:||..|..|:.|...|.
Zfish    74 NQMMTTNVWVKQEWNDYKLRWNPEEYENVTSIRIPSEIIWRPDIVLYNNADGDFAVTHLTKAQVF 138

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202
            :||...:.||.|:||:|.||:|:||||.|:|:|||||||||..::||:..:.| .|..|:..:||
Zfish   139 YNGRIKWKPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDRAKIDLISMASD-VDQMDYWESGE 202

  Fly   203 WYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGE 267
            |.::...|..|...|.||.|.|.|||::..|||..|:|..|||:||:|||.:.:|.|.||.:..|
Zfish   203 WVIINAVGTYNIKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECAE 267

  Fly   268 KLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTY 332
            |:||.:::||||||||.|:.|.:|:||..:||||..:|.:
Zfish   268 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT------------------------- 307

  Fly   333 FNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP---GRKITRKTIL 394
                |..|..|:::||.|||.|||::..|.||.|::.:||..:|..|.|.||   |::...|.|
Zfish   308 ----MIFVTLSIIITVFVLNVHHRSSRTHSMPHWVRQLFLHLVPRYLFMKRPPASGKRNCGKLI- 367

  Fly   395 LSNRMKELELKERSSKSLLA--NVLDIDDD---------------------------FRHTISGS 430
                  |:..|:.:|:|:..  |:|||...                           |..:...|
Zfish   368 ------EMMHKQANSQSMFLRNNILDISPQSPIPHLGPTSAAQQDQVQQDSTSPKPLFFCSSPSS 426

  Fly   431 QTAI--------------------------GSSASF---------------GRPTT--------- 445
            |.:|                          .|:.||               |..:|
Zfish   427 QYSILQEENSQTPQTPVLSYTCAYTNSIFASSTTSFPDTLLGTLLHTIPQDGAKSTECDFQGHSA 491

  Fly   446 ----VEEHHTAIG---CNH--------------------------------------KDLHL--- 462
                :|...:.:|   |.|                                      .||:.
Zfish   492 ESVFMEAKESVLGAGSCQHCLTSEGTSLQKLDLDEAGRCTRHNMPSAQIFSPSSDGSTDLNAAEP 556

  Fly   463 -------ILKEL---QFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
                   :||.|   |:|...:|..|.:..:..|||:.|||:||..|.:|.|..|:.||.:.|
Zfish   557 VSNLSQSLLKALEGVQYIADHLRAEDSDFSVREDWKYVAMVIDRIFLWMFVLVCILGTVGLFL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	214/648 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	88/180 (49%)
chrna4b	NP_001041528.1	Neur_chan_LBD	31..237	CDD:280998	103/206 (50%)
		Neur_chan_memb	244..618	CDD:280999	102/409 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910