Protein Alignment nAChRalpha6 and chrna10a

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_021337092.1
• Gene: chrna10a / 556507
• ZFINID: ZDB-GENE-060503-725
• Length: 532
• Species: Danio rerio
• Alignment Length: 558
• Identity: 187/558 - (33%)
• Similarity: 290/558 - (51%)
• Gaps: 87/558 - (15%)

  Fly     9 LSLFVLLIFLAIIKESC---QGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |..|...:...:|...|   .|.:.::|||.|.:.|.:..|||.:..:.|.|...:||.||||:|
Zfish     6 LQYFTFCVVCHMIIPVCWGANGIYAQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMD 70

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |:|||||...|:...|.|..|.||:..|.|:..:||..:.:|:||:::|||||:.|..|..||:|
Zfish    71 ERNQILTAYLWIRQVWIDKYLTWNKENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVV 135

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITN 200
            ::|:|..::..|.|.||:||:|:::||||.|.|.:.:|||||:||||| :||:.:..||:|.:.|
Zfish   136 IRHDGQIMWDAPAITKSSCKVDVSFFPFDAQQCRLTYGSWTYNGNQLD-ILNAMESADLADLVDN 199

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            .||.:|.||.|:|.|:|.||.:||.|:|:|::::||..:|.|||::|||:||.:|.|||.||.||
Zfish   200 VEWEVLGMPAKRNIILYGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADS 264

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||::||||::|:||||..||||.||.                              |:.:||:|
Zfish   265 GEKVSLGVTVMLALTVFQLLVAEIMPP------------------------------SENVPLIG 299

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM-------------- 381
            .|:...|.|:.:|..||:.|:|.||...|...:|.|.|...||:|..|..:
Zfish   300 KYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYLARICFVYEVGENCMTPQPEK 364

  Fly   382 ----------------GRPGR-----KITRKTILLSNRMKELELKERSSKSLLANVLDIDDD--- 422
                            |:.|:     |..|.....|.::  ||.:|..|: :|:....:...
Zfish   365 PDPQPQKPQDCNCNMNGQAGKDDFVFKFDRNQEATSPKL--LEDREDMSQ-ILSPACSLGKHPTC 426

  Fly   423 ----FRHTISGSQTAIGSSASFGRP-----TTVEEHHTAI--GCNHKDLHLILKELQFITARMRK 476
                ::..:..|......:|..|:|     ....:|.:..  .|.....|| |:.::::....|.
Zfish   427 RYGVWKEGVFMSMDCGDGAAETGKPIGRGQEGCRDHDSGFKSQCKCDQQHL-LRNIEYVANCYRD 490

  Fly   477 ADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVL 514
            ....|...|:||..|.|:|||.:.:|.:.....::.::
Zfish   491 QRATARRTGEWKKVAKVLDRFFMWLFFIMVFFMSLLIM 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	186/556 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	85/180 (47%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrna10a	XP_021337092.1	LIC	31..422	CDD:455710	162/424 (38%)
		LGIC_ECD_nAChR_A10	55..235	CDD:349824	85/180 (47%)
		Cys-loop	154..168	CDD:349824	8/13 (62%)