DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and chrna10a

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_021337092.1	Gene:	chrna10a / 556507	ZFINID:	ZDB-GENE-060503-725	Length:	532	Species:	Danio rerio

Alignment Length:	558	Identity:	187/558 - (33%)
Similarity:	290/558 - (51%)	Gaps:	87/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSLFVLLIFLAIIKESC---QGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |..|...:...:|...|   .|.:.::|||.|.:.|.:..|||.:..:.|.|...:||.||||:|
Zfish     6 LQYFTFCVVCHMIIPVCWGANGIYAQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMD 70

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |:|||||...|:...|.|..|.||:..|.|:..:||..:.:|:||:::|||||:.|..|..||:|
Zfish    71 ERNQILTAYLWIRQVWIDKYLTWNKENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVV 135

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITN 200
            ::|:|..::..|.|.||:||:|:::||||.|.|.:.:|||||:||||| :||:.:..||:|.:.|
Zfish   136 IRHDGQIMWDAPAITKSSCKVDVSFFPFDAQQCRLTYGSWTYNGNQLD-ILNAMESADLADLVDN 199

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            .||.:|.||.|:|.|:|.||.:||.|:|:|::::||..:|.|||::|||:||.:|.|||.||.||
Zfish   200 VEWEVLGMPAKRNIILYGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADS 264

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||::||||::|:||||..||||.||.                              |:.:||:|
Zfish   265 GEKVSLGVTVMLALTVFQLLVAEIMPP------------------------------SENVPLIG 299

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM-------------- 381
            .|:...|.|:.:|..||:.|:|.||...|...:|.|.|...||:|..|..:
Zfish   300 KYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYLARICFVYEVGENCMTPQPEK 364

  Fly   382 ----------------GRPGR-----KITRKTILLSNRMKELELKERSSKSLLANVLDIDDD--- 422
                            |:.|:     |..|.....|.::  ||.:|..|: :|:....:...
Zfish   365 PDPQPQKPQDCNCNMNGQAGKDDFVFKFDRNQEATSPKL--LEDREDMSQ-ILSPACSLGKHPTC 426

  Fly   423 ----FRHTISGSQTAIGSSASFGRP-----TTVEEHHTAI--GCNHKDLHLILKELQFITARMRK 476
                ::..:..|......:|..|:|     ....:|.:..  .|.....|| |:.::::....|.
Zfish   427 RYGVWKEGVFMSMDCGDGAAETGKPIGRGQEGCRDHDSGFKSQCKCDQQHL-LRNIEYVANCYRD 490

  Fly   477 ADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVL 514
            ....|...|:||..|.|:|||.:.:|.:.....::.::
Zfish   491 QRATARRTGEWKKVAKVLDRFFMWLFFIMVFFMSLLIM 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	186/556 (33%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	85/180 (47%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	162/424 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920