Protein Alignment nAChRalpha6 and CHRNA9

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 169/507 - (33%)
• Similarity: 274/507 - (54%)
• Gaps: 64/507 - (12%)

  Fly    23 ESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWN 87
            |:..|.:.::|.|.|...|:...|||.:..:.|.|...:||.||.|:||:|||||...|:...|:
Human    24 ETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWH 88

  Fly    88 DYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKS 152
            |..|.|:..:|.|:..:||..:.:|:||:::||.||:......:||:|::::|...:..|.|.||
Human    89 DAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKS 153

  Fly   153 TCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVY 217
            :|.:|:|:||||:|.|.:.||||||:|||:| :.|:.|.|||||||.:.||.:..||..||.|.|
Human   154 SCVVDVTYFPFDNQQCNLTFGSWTYNGNQVD-IFNALDSGDLSDFIEDVEWEVHGMPAVKNVISY 217

  Fly   218 ACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVF 282
            .||.|||.|:|||:.::||:.:|..||::||||||.:|.|.|.||..||||::|||||||::|||
Human   218 GCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVF 282

  Fly   283 LNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLT 347
            ..:|||.||                              .|:.:||:|.|:...|.::.:|..||
Human   283 QLMVAEIMP------------------------------ASENVPLIGKYYIATMALITASTALT 317

  Fly   348 VVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL------------RMGRPGRKITRKTILLSNRMK 400
            ::|:|.|...|:...:|.|.:.|.|:::..:|            ...|....:|:    :.:::.
Human   318 IMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTK----VYSKLP 378

  Fly   401 ELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILK 465
            |..||...:|. |:...|::...::.: |.|         |:.....|.:.|      ...::.:
Human   379 ESNLKAARNKD-LSRKKDMNKRLKNDL-GCQ---------GKNPQEAESYCA------QYKVLTR 426

  Fly   466 ELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            .:::|...::..........:||..|.|:|||.:.:|.:...:.|:.::..|
Human   427 NIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	168/505 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:273305	168/501 (34%)
		Neur_chan_LBD	31..236	CDD:280998	90/205 (44%)
		Neur_chan_memb	244..474	CDD:280999	72/280 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920