Protein Alignment nAChRalpha6 and chrnd

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001015814.1
• Gene: chrnd / 548531
• XenbaseID: XB-GENE-989975
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 170/542 - (31%)
• Similarity: 264/542 - (48%)
• Gaps: 82/542 - (15%)

  Fly     9 LSLFVLLIFLAIIKESCQGPHEKRLLNHLLST--YNTLERPVANESEPLEVKFGLTLQQIIDVDE 71
            |.|.:...|...:.||    .|:|||||:...  |....|||.:..|.:.|...|||..:|.:.|
 Frog     8 LLLPIFSYFQGCLSES----EEERLLNHIFGERGYRKELRPVEHTGETVNVSLALTLSNLISLKE 68

  Fly    72 KNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVV 136
            .::.||||.|:.|.|.|..|.|:..|:..:..:|:.|:.:|:|.:::.|:.:..|:..|::|::|
 Frog    69 ADETLTTNVWVELGWYDKRLAWDMEEFHHINIIRVPPDMVWQPQLILENNNNGVFEVAYYSNVLV 133

  Fly   137 KHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------- 192
            ..:|...::||.||:::|.|::.:||||.|:|.:||.|.||:..:::|.|..:...
 Frog   134 NSDGFMYWLPPAIFQTSCSINVNYFPFDWQNCSLKFSSLTYNAKEINLQLRQDQDEESQRNYPVE 198

  Fly   193 ----DLSDFITNGEWYLLAMPGKKNTIVYACCPE--PYVDITFTIQIRRRTLYYFFNLIVPCVLI 251
                |...|..||||.::.:|.||| |..:..||  .|.||||.:.|:|:.|:|..|::.|||||
 Frog   199 WIIIDPEGFTENGEWEIVHIPAKKN-IDRSLTPESTKYQDITFYLIIKRKPLFYIINILAPCVLI 262

  Fly   252 SSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316
            :.||.|.|.||.|||||:||.:::||:.:|||.|:::.:|.||.|:|||
 Frog   263 ALMANLVFYLPADSGEKMTLAISVLLAQSVFLLLISQRLPETSFAIPLI---------------- 311

  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM 381
                         ..|...||.:|...||..|:|||.|.||...|.:...:|.:||..||.||.|
 Frog   312 -------------SKYLMFIMVLVTIVVVSCVIVLNLHFRTPSTHVITERMKEIFLNKLPRILHM 363

  Fly   382 GRPGRK--------ITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSA 438
            .||...        :.|::..:...:|..|.....|:|.|  :.:...: ||.::...|
 Frog   364 SRPAEPEPEPWSGVLLRRSSSVGYIVKAEEYYSVKSRSEL--MFEKQSE-RHGLTSRAT------ 419

  Fly   439 SFGRPTTVEEHHTAIGCNHK------DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRF 497
                |..|    ..:..|:.      ::...:....||...||..:|..|...:|...|..|||.
 Frog   420 ----PARV----NPLNSNNSQDQLYGEIKPAIDGANFIVKHMRDKNDYNEEKDNWYRIARTVDRL 476

  Fly   498 CLIVFTLFTIIATVTVLLSAPH 519
            ||.:.|...||.|:.:.|...:
 Frog   477 CLFLVTPVMIIGTLWIFLGGAY 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	169/536 (32%)
		LGIC_ECD_nAChR	55..236	CDD:349798	65/195 (33%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
chrnd	NP_001015814.1	LGIC_ECD	26..248	CDD:475126	76/222 (34%)
		Neur_chan_memb	255..493	CDD:460753	84/283 (30%)