Protein Alignment nAChRalpha6 and Chrna10

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001074893.1
• Gene: Chrna10 / 504186
• MGIID: 3609260
• Length: 447
• Species: Mus musculus
• Alignment Length: 509
• Identity: 170/509 - (33%)
• Similarity: 255/509 - (50%)
• Gaps: 77/509 - (15%)

  Fly    12 FVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            |:||:||.......:|....:|...|.:.|.:..||||:..:.|.|...:||.||||:||:||:|
Mouse    12 FLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVL 76

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGS 141
            |...|:..||.|..|.|:...||.:..:||..:.:|:||:::||.||.....:..||:||:|:|:
Mouse    77 TLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGA 141

  Fly   142 CLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLL 206
            ..:..|.|.:|:|::|::.||||.|.|.:.|||||:.|:||| |........|:||:.|.||.:|
Mouse   142 VRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLD-VRPRGTSASLADFVENVEWRVL 205

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            .||.::..:.|.||.|||.|:|||:.:|||...|..||::|||.||.:|.|.|.||.|||||::|
Mouse   206 GMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSL 270

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            |||:||:||||..::|||||.                              ::::||:|.|:...
Mouse   271 GVTVLLALTVFQLILAESMPP------------------------------AESVPLIGKYYMAT 305

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKE 401
            |.||..|..||::::|.|:...:.|.:|.|                       .:.:||.:..|.
Mouse   306 MTMVTFSTALTILIMNLHYCGPNAHPVPAW-----------------------ARVLLLGHLAKG 347

  Fly   402 LELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEE---HHTAIGCNHKDLHLI 463
            |.::||...                 .|....:.|:.|...|.....   |.....|:.:.|
Mouse   348 LCVRERGEP-----------------CGQSKPLESAPSLQPPAGPPAGPCHEPRCLCHQEAL--- 392

  Fly   464 LKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            |..:..|....|..........|||..|.|:|||.|.:|....::.::.||:.|
Mouse   393 LHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLLVLVQA 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	169/507 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	78/180 (43%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:355788	86/206 (42%)
		LGIC_TM_cation	239..>324	CDD:349853	44/114 (39%)
		TM1 helix	239..261	CDD:349853	11/21 (52%)
		Neur_chan_memb	243..437	CDD:367256	72/266 (27%)
		TM2 helix	269..290	CDD:349853	13/20 (65%)
		TM3 helix	300..322	CDD:349853	7/21 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10642
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920