Protein Alignment nAChRalpha6 and Chrna10

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001074893.1
• Gene: Chrna10 / 504186
• MGIID: 3609260
• Length: 447
• Species: Mus musculus
• Alignment Length: 509
• Identity: 170/509 - (33%)
• Similarity: 255/509 - (50%)
• Gaps: 77/509 - (15%)

  Fly    12 FVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            |:||:||.......:|....:|...|.:.|.:..||||:..:.|.|...:||.||||:||:||:|
Mouse    12 FLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVL 76

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGS 141
            |...|:..||.|..|.|:...||.:..:||..:.:|:||:::||.||.....:..||:||:|:|:
Mouse    77 TLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGA 141

  Fly   142 CLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLL 206
            ..:..|.|.:|:|::|::.||||.|.|.:.|||||:.|:||| |........|:||:.|.||.:|
Mouse   142 VRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLD-VRPRGTSASLADFVENVEWRVL 205

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            .||.::..:.|.||.|||.|:|||:.:|||...|..||::|||.||.:|.|.|.||.|||||::|
Mouse   206 GMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSL 270

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            |||:||:||||..::|||||.                              ::::||:|.|:...
Mouse   271 GVTVLLALTVFQLILAESMPP------------------------------AESVPLIGKYYMAT 305

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKE 401
            |.||..|..||::::|.|:...:.|.:|.|                       .:.:||.:..|.
Mouse   306 MTMVTFSTALTILIMNLHYCGPNAHPVPAW-----------------------ARVLLLGHLAKG 347

  Fly   402 LELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEE---HHTAIGCNHKDLHLI 463
            |.::||...                 .|....:.|:.|...|.....   |.....|:.:.|
Mouse   348 LCVRERGEP-----------------CGQSKPLESAPSLQPPAGPPAGPCHEPRCLCHQEAL--- 392

  Fly   464 LKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            |..:..|....|..........|||..|.|:|||.|.:|....::.::.||:.|
Mouse   393 LHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLLVLVQA 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	169/507 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	78/180 (43%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:475126	86/206 (42%)
		LGIC_TM_cation	239..>324	CDD:349853	44/114 (39%)
		TM1 helix	239..261	CDD:349853	11/21 (52%)
		Neur_chan_memb	243..437	CDD:460753	72/266 (27%)
		TM2 helix	269..290	CDD:349853	13/20 (65%)
		TM3 helix	300..322	CDD:349853	7/21 (33%)