Protein Alignment nAChRalpha6 and pHCl-2

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 603
• Identity: 109/603 - (18%)
• Similarity: 196/603 - (32%)
• Gaps: 193/603 - (32%)

  Fly     8 SLSLFVLLIFLAIIKESCQGPH------------------------------------------- 29
            :|.:|||:.:|.:  .|..|.|
  Fly     3 TLGIFVLISYLGL--SSAAGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLK 65

  Fly    30 --EKRLLNHLLS------TYNTLERPVAN----ESEPLEVKFGLTLQQIIDVDEKNQILTTNAWL 82
              |...|..||:      .|:.:..||.:    |..|:::.....:..:.::|..:...|....|
  Fly    66 NAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLL 130

  Fly    83 NLEWNDYNLRWNETEYGGVKDLRITPNK-------------LWKPDVLMYNSADEGFDGTYHTNI 134
            .|.:.|..|.::.          ..||:             ||.|.:.:.|.......||
  Fly   131 QLRYLDPRLAFSS----------YLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGT----- 180

  Fly   135 VVKHNGSCLYVPPGIFKST-------CKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG 192
            ..|...:.:|....:..||       |.::...||||:|.|:....||.|:...:.|...:::..
  Fly   181 SAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPV 245

  Fly   193 DLSDFITNGEWYLLA-------MPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVL 250
            .....:...|:.|:.       ....::.:.:......|..|:||:.:.|...||..:..:|.::
  Fly   246 SFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIM 310

  Fly   251 ISSMALLGFTLPPD-SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNL 314
            |.:::.:.|.|..| :..:.|||.|.|||.                        |.|||:...||
  Fly   311 IVTISWVSFWLQADQTPARTTLGCTTLLSF------------------------ITLSLSQENNL 351

  Fly   315 VAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL 379
            :..:...:|:.     .:..|.:|:..|.|....|
  Fly   352 MKVSYVTMSEV-----WFLVCTIFIFGSLVEFAFV------------------------------ 381

  Fly   380 RMGRPGRKITRKTILLSNRMKELELKERSSKSLLAN--VLDIDDDFRHTISGSQTAIGSSASFGR 442
                       .||.  .|..:|:||:|::|.::.:  |..:....||....:.:.:.:.::...
  Fly   382 -----------NTIW--RRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSM 433

  Fly   443 PTTVEEHHTAI----------GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMV---- 493
            ..|...::|.|          ..:.:|..:.|.| |..|:....:|...|.... .||.|.
  Fly   434 DKTCGPNNTVITIETPIIIGGSLSREDSAISLDE-QDETSTSESSDSSKEKPAQ-TFATMTPKEV 496

  Fly   494 ---VDRFCLIVFTLFTII 508
               :||....||.|..|:
  Fly   497 SLWIDRKMRFVFPLSFIV 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	108/600 (18%)
		LGIC_ECD_nAChR	55..236	CDD:349798	35/207 (17%)
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	101/558 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030