Protein Alignment nAChRalpha6 and nAChRalpha1

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 201/584 - (34%)
• Similarity: 291/584 - (49%)
• Gaps: 116/584 - (19%)

  Fly    10 SLFVLLIFLAI--IKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            |:....:|:|:  .......|..|||.:.|||.||.|.|||.|.|:.|.||.||.|.|:|||:.|
  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            |||:|||.|:..|||||.|:||..:||||..|.:....:|.||:::||:||..::.|..|..::.
  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL--------VLNSEDGGDL 194
            |.|..::.||.|:||.|:||:.:||||:|.|.||||||||||..:||        ..|.|.|.||
  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197

  Fly   195 SDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGF 259
            .|:..:.||.::.:|..:|...|:||.|||:||.|.:.:||:||:|..|||:|||.||.:::|.|
  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262

  Fly   260 TLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSD 324
            .||.|||||::|.::||||||||..|:||.:|.|             ||||
  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPT-------------SLTV-------------- 300

  Fly   325 AIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKIT 389
              ||||.|....|.:|..|||:|:.|||.:.|:...|.|.||::.:|:|.||.:|.:.||
  Fly   301 --PLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERP----- 358

  Fly   390 RKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAI- 453
                      |:.|.:|.....:|.:|..:..|....::......  |..:|.|.....|...:
  Fly   359 ----------KKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRF--SGDYGIPALPASHRFDLA 411

  Fly   454 ----------------------------------------GC-------------------NHKD 459
                                                    ||                   ..::
  Fly   412 AAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYARE 476

  Fly   460 LHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ 523
            :...::..:||...::..|....:..|||:.|||:||..|.:|.:..::.|..::|.||.:..|
  Fly   477 MEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQ 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	197/575 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	88/188 (47%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	103/214 (48%)
		LIC	27..530	CDD:273305	192/548 (35%)
		Neur_chan_memb	247..530	CDD:280999	86/328 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940