Protein Alignment nAChRalpha6 and GluClalpha

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 106/527 - (20%)
• Similarity: 201/527 - (38%)
• Gaps: 145/527 - (27%)

  Fly    30 EKRLLNHLLST--YNTLERP--VANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYN 90
            ||::|:.:|..  |:...||  :.....|..|:..:.::.|..:|:.....:.......:|.|..
  Fly    33 EKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDER 97

  Fly    91 LRWNETEYGGVKDLRIT-PNKLWKPDVLMYNSADEGFDGTYHTNIVVK--HNGSCLYVPPGIFKS 152
            |::::.: |.:|.|.:| .|::|.||:...|..:..|......|:.::  .|||.||........
  Fly    98 LKFDDIQ-GRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTL 161

  Fly   153 TCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG-------------DLSDFITNGEWY 204
            .|.:::..:|.|.|.|.::..|:.:..|  |||...::|.             .|..|:|:
  Fly   162 ACPMNLKLYPLDRQICSLRMASYGWTTN--DLVFLWKEGDPVQVVKNLHLPRFTLEKFLTD---- 220

  Fly   205 LLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSG--- 266
              ....|.||..|:|..   ||:.|    :|...||...:.:||.::..::.:.|.|  |.|
  Fly   221 --YCNSKTNTGEYSCLK---VDLLF----KREFSYYLIQIYIPCCMLVIVSWVSFWL--DQGAVP 274

  Fly   267 EKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGT 331
            .:::||||.||::....:.:..|:|.         |:...::.|:..:
  Fly   275 ARVSLGVTTLLTMATQTSGINASLPP---------VSYTKAIDVWTGV----------------- 313

  Fly   332 YFNCIMFMVASSVVLTVVVLNYHHRT----ADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKT 392
               |:.|:..:  :|...::||..|:    |::|:
  Fly   314 ---CLTFVFGA--LLEFALVNYASRSGSNKANMHK------------------------------ 343

  Fly   393 ILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASF------GRPTTVEEHHT 451
               .|..|:....|::|....:::||.|.:....:: ||.|.|.....      |.|..:|:.
  Fly   344 ---ENMKKKRRDLEQASLDAASDLLDTDSNATFAMA-SQFARGGGQQKPLVRHPGDPLALEKR-- 402

  Fly   452 AIGCNHKDLHLILKE--------LQFITARMRKADDEAELIGDWKFAAMVVDRFCL-IVFTLFTI 507
             :.|   ::|:...:        |.....|.::.|              |:.|... :||.||.:
  Fly   403 -LQC---EVHMQAPKRPNCCKTWLSKFPTRSKRID--------------VISRITFPLVFALFNL 449

  Fly   508 IATVTVL 514
            :...|.|
  Fly   450 VYWSTYL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	106/527 (20%)
		LGIC_ECD_nAChR	55..236	CDD:349798	44/196 (22%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	104/524 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030