Protein Alignment nAChRalpha6 and nAChRalpha4

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 201/547 - (36%)
• Similarity: 285/547 - (52%)
• Gaps: 102/547 - (18%)

  Fly    28 PHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLR 92
            |..|||.:.|||.||.|.|||.|.::.|:|...|.|.|:|||:.||||:|||.|:...|.||.||
  Fly    10 PDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR 74

  Fly    93 WNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKID 157
            |...|||||..|.:..:.:|:||:::||:||..|:.|..|...:...|...:.||.|:||:|:||
  Fly    75 WEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEID 139

  Fly   158 ITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITNGEWYLLAMPGKKNT 214
            :.:||||:|.|.:|||||||||.::||....|..|        |||:|..:.||.:|.:|..:|.
  Fly   140 VEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNE 204

  Fly   215 IVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSL 279
            ..|.||.|||:||||.|.:||:||:|..|:|:||:.||.:.:|.|.||.|||||:||.::||:||
  Fly   205 KFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISL 269

  Fly   280 TVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSV 344
            .||..||.|.:|.||                   ||          :||||.|....|.:|:.|:
  Fly   270 HVFFLLVVEIIPPTS-------------------LV----------VPLLGKYLIFAMILVSISI 305

  Fly   345 VLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILL-------------- 395
            .:||||||.|.|:...|:|.||:|.||:.:||..|.:.||........:||
  Fly   306 CVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSAT 370

  Fly   396 ------SNRMKELELKERSSKSLLAN--------------------------VLDIDDDFRHTIS 428
                  |:.......||..|:|:.||                          |.|:|      |.
  Fly   371 NIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMD------IG 429

  Fly   429 --GSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAA 491
              |.::.|.::.:|.....:.:.|.:..|           ::||....:..:|..::..|||:.|
  Fly   430 PLGMKSPILNNPAFSHSKCLPKIHKSCFC-----------VRFIAEHTKMQEDSTKVKEDWKYVA 483

  Fly   492 MVVDRFCLIVFTLFTIIATVTVLLSAP 518
            ||:||..|.:|||..::.|..::|.||
  Fly   484 MVLDRLFLWIFTLAVVVGTAGIILQAP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	199/544 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	87/188 (46%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	198/540 (37%)
		Neur_chan_LBD	12..227	CDD:280998	101/214 (47%)
		Neur_chan_memb	234..505	CDD:280999	92/316 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940