Protein Alignment nAChRalpha6 and chrnd

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_996947.1
• Gene: chrnd / 404273
• ZFINID: ZDB-GENE-030131-6665
• Length: 518
• Species: Danio rerio
• Alignment Length: 544
• Identity: 171/544 - (31%)
• Similarity: 265/544 - (48%)
• Gaps: 88/544 - (16%)

  Fly     5 LPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLST--YNTLERPVANESEPLEVKFGLTLQQII 67
            |.|||..|       |.:|.|....|:||:|:|...  ||...|||.|:.|.:::...|||..:|
Zfish     7 LTASLLCF-------IFQECCGRNEEERLINYLFKERGYNKELRPVQNKDETVDIYLALTLSNLI 64

  Fly    68 DVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHT 132
            .:.|.::.|.||.|:...|.|:.|.|||:|| .:..||:.|:.:|.|::::.|:.|..|...|:.
Zfish    65 SLKEVDETLLTNVWMEHGWKDHRLTWNESEY-DIPVLRLPPSMVWLPEIVLENNNDAQFQVAYYC 128

  Fly   133 NIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG----- 192
            |:::..:|...::||.||:|:|.|::.:||||.|:|.:||.|.||:..::.|.|..|...
Zfish   129 NVLIYSSGDMYWLPPAIFRSSCSINVNYFPFDWQNCSLKFSSLTYNAKEISLNLKMEQENTTYYK 193

  Fly   193 ------DLSDFITNGEWYLLAMPGKKNTIVYACCPE---PYVDITFTIQIRRRTLYYFFNLIVPC 248
                  |...|..||||.::..|.::|  :|...|:   .:.||||.:.|:|:.|:|..|:|:||
Zfish   194 VEWIIIDPEGFTENGEWEIVHKPARRN--IYKSIPKESNKHQDITFYLIIKRKPLFYIVNIIIPC 256

  Fly   249 VLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLN 313
            ||||.:|.|.:.||.|||||:||.:::||:.:|||.|:::.:|.||.||||| |..|:.:.|.:.
Zfish   257 VLISFLASLVYYLPADSGEKMTLSISVLLAQSVFLLLISQRLPETSMAVPLI-VKYLMFIMVLVT 320

  Fly   314 LVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWI 378
            :|.                .||            |:|||.|.||...|.|..|.|..||:.||.:
Zfish   321 VVV----------------LNC------------VIVLNLHFRTPSTHVMTEWTKEFFLERLPRL 357

  Fly   379 LRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF---------------RHTIS 428
            |.|..|         :....:.|..|..|||.  |..:...::.:               ||.::
Zfish   358 LHMSLP---------VEDQPVPESALPRRSSS--LGYIAQAEEYYSVKSRSELMFEKQSERHGLA 411

  Fly   429 GSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMV 493
            ...|...:..|.......|:       .:.::...::...:|...|...:|..|...:|...|..
Zfish   412 ARPTPKATYTSSNDSEVSEQ-------LYNEMKPAVEGANYIVKHMHDKNDYNEEKDNWSGIART 469

  Fly   494 VDRFCLIVFTLFTIIATVTVLLSA 517
            |||.|..|.|...:|.|:.:.|.|
Zfish   470 VDRLCFYVVTPVMMIGTICIFLMA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	166/536 (31%)
		LGIC_ECD_nAChR	55..236	CDD:349798	64/194 (33%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
chrnd	NP_996947.1	LGIC_ECD_nAChR_D	26..245	CDD:349829	76/221 (34%)
		Cys-loop	150..164	CDD:349829	7/13 (54%)
		Neur_chan_memb	252..490	CDD:460753	81/284 (29%)