Protein Alignment nAChRalpha6 and SecCl

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 110/494 - (22%)
• Similarity: 189/494 - (38%)
• Gaps: 108/494 - (21%)

  Fly    11 LFVLLIFLAI-IK---ESCQGP------HEKRLLNHL--LSTYNTLERPVANESE----PLEVKF 59
            :.||.|:.:: :|   |.|...      .:.:|:..|  :..|:.||||...:|:    |:.||.
  Fly    15 ILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKT 79

  Fly    60 GLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYG----GVKDLRITPNKLWKPDVLMYN 120
            .:.:..:.:::........:|.|.|.:.|..|.:......    |.|.|   ..:||.|.:...|
  Fly    80 RIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL---SERLWLPHIFFAN 141

  Fly   121 SADEGFDGTYHTNIVVKHNGSCLYVPPG-IFKST-------CKIDITWFPFDDQHCEMKFGSWTY 177
            ..:....||...:::...:      |.| :..||       |.::...||||.|.|.....||.|
  Fly   142 ERESSILGTDEKDVLTSLS------PEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMY 200

  Fly   178 DGNQLDLVLNSEDGGDLS-DFITNGEWYLLAMPGKKNTIV--------YACCPEPYVDITFTIQI 233
              |..||:|..|....:| |.......|.:|......|||        :......|..::||:.:
  Fly   201 --NTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNL 263

  Fly   234 RRRTLYYFFNLIVPCVLISSMALLGFTLPPD-SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAV 297
            :|...:|..:..:|.::|.:::.:.|.|..| |..::.||.:.:||   |:.|.:..
  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLS---FITLSSSQ-------- 317

  Fly   298 PLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHE 362
                              ::.||:|| .|.:...:|....|.:..|:|....|.....|..:|.
  Fly   318 ------------------SKNLPKVS-YIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIE- 362

  Fly   363 MPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTI 427
                :|.|..:::.......||.|:....:  |||     |.:.||..| |.|::...:..|
  Fly   363 ----LKKVNSKYIIKSTLTPRPARRQIGGS--LSN-----ESRARSCSS-LDNIVSSTESVR--- 412

  Fly   428 SGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKE 466
            :|:.|.   :..|....||          |.:|.:|..|
  Fly   413 NGNGTV---NQGFNNYLTV----------HPNLPIIRTE 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	110/494 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	45/201 (22%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	104/466 (22%)
		Neur_chan_LBD	44..267	CDD:280998	55/233 (24%)
		Neur_chan_memb	275..503	CDD:280999	48/223 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030