Protein Alignment nAChRalpha6 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 115/502 - (22%)
• Similarity: 186/502 - (37%)
• Gaps: 137/502 - (27%)

  Fly    29 HEKRLLNHL-------------LSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNA 80
            ::||||..:             ::|.....||  :....|.|...:.|..:...||.:.......
  Fly   350 YDKRLLPPVNDEDFCCGLQSPDMATNQNARRP--HNRGTLTVNVNVLLLSLASPDESSLKYEVEF 412

  Fly    81 WLNLEWNDYNLRW-NETEYGGVKDLRITPNKLWKPDV--LMYNSADEGFDGTYHTNIVVKH---- 138
            .||.:|||..|:: |::.|..:..|. ..:.:|.||.  :|:        |.:...|:..|
  Fly   413 LLNQQWNDPRLQYGNKSHYDFLNALH-HHDSIWTPDTYFIMH--------GDFKDPIIPMHFALR 468

  Fly   139 ---NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLV-LNSEDGGDLSDFIT 199
               ||:..|........:|:..:..|||||..|.....|.:|:..|:..| .|.||....|..:|
  Fly   469 IFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLT 533

  Fly   200 NGEWYLLAMPGKKNTIV---------YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMA 255
            ....||:    |..|..         |:|.   .|::|||    |...|||..:.:|.:::.:.:
  Fly   534 TLNAYLI----KNQTTACDQNSWRGNYSCL---QVELTFT----RDRAYYFTTVFIPGIILVTSS 587

  Fly   256 LLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVP---LIGVTILLSLTVFLNLVAE 317
            .:.|.|                               ..:|||   :||||.:|:.....|....
  Fly   588 FITFWL-------------------------------EWNAVPARVMIGVTTMLNFFTTSNGFRS 621

  Fly   318 TLPQVSDAIPLLGTYFN-----CIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPW 377
            |||.||:.     |..|     |:.|:.||  :|..|.:||..|...:|.:
  Fly   622 TLPVVSNL-----TAMNVWDGVCMCFIYAS--LLEFVCVNYVGRKRPLHNV-------------- 665

  Fly   378 ILRMGRPGRK-ITRKTILLSNRMKELELKERSS------KSLLANVLDIDDDFRHTISGSQTAIG 435
               :.|||.. :|::...:.:|:..:.....:|      .|::.....:.       ||:..|..
  Fly   666 ---VYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMS-------SGTPAASS 720

  Fly   436 SSASFGRP-TTVEEHHTAIGCNHKDLH--LILKELQFITAR--MRKA 477
            |.|:.|.| .|..|.....|...::.|  :|...:|.:.||  .|||
  Fly   721 SVATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKA 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	115/502 (23%)
		LGIC_ECD_nAChR	55..236	CDD:349798	50/200 (25%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	89/371 (24%)
		LGIC_TM	<948..975	CDD:476813
		TM4 helix	950..971	CDD:349850