Protein Alignment nAChRalpha6 and chrna1.2

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_012825723.1
• Gene: chrna1.2 / 394991
• XenbaseID: XB-GENE-5932067
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 509
• Identity: 188/509 - (36%)
• Similarity: 280/509 - (55%)
• Gaps: 81/509 - (15%)

  Fly    15 LIFLAIIKESCQGP-----HEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQ 74
            |||..|    ..||     ||.||:..|.:.||.:.|||....:.:.|..||.|.|:|:|||.||
 Frog     8 LIFFFI----AAGPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQ 68

  Fly    75 ILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHN 139
            |::||..|..:|.|.||:|:..:|||||.|||..:::|.||:::||:||..|..:..|.|:::|.
 Frog    69 IVSTNIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKILLEHT 133

  Fly   140 GSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSE-DGGDLSDFITNGEW 203
            |...:.||.||||.|:|.:|.||||.|:|.||||:|||||..  :|:|.: |..|||:|:.:|||
 Frog   134 GKITWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTL--VVINPDRDRPDLSNFMASGEW 196

  Fly   204 YLLAMPGKKNTIVYACCPE-PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGE 267
            .:......|:.:.|.|||: ||:|||:...::|..||:..|:|:||:|.|.:..|.|.||.||||
 Frog   197 MMKDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGE 261

  Fly   268 KLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTY 332
            |:||.:::||||||||.::.|.:|:||.||||||..:|.:
 Frog   262 KMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFT------------------------- 301

  Fly   333 FNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL---RMGRPGRKITRKTIL 394
                |..|.:|:::||:|:|.|||:...|.||||::.:|:..:|.|:   .|.||.
 Frog   302 ----MVFVIASIIITVIVINTHHRSPSTHTMPPWVRKIFIDTIPNIMFFSTMKRPS--------- 353

  Fly   395 LSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKD 459
                      :|:..::..|..:||.|     |||.   :|       |..|.....|:  .:.|
 Frog   354 ----------QEKQPQTTFAEEMDISD-----ISGK---LG-------PAAVTYQSPAL--KNPD 391

  Fly   460 LHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513
            :...::.:::|...|:...:..:...:|||.|||:|...|.||....:|.|:.|
 Frog   392 VKSAIEGIKYIAETMKSDQESNKASEEWKFVAMVLDHILLAVFMTVCVIGTLAV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	188/509 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	84/182 (46%)
chrna1.2	XP_012825723.1	LIC	8..447	CDD:273305	188/509 (37%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	95/210 (45%)
		Cys-loop	148..162	CDD:349815	8/13 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9936
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000