Protein Alignment nAChRalpha6 and chrna7a

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_957513.1
• Gene: chrna7a / 394199
• ZFINID: ZDB-GENE-040108-3
• Length: 509
• Species: Danio rerio
• Alignment Length: 524
• Identity: 232/524 - (44%)
• Similarity: 312/524 - (59%)
• Gaps: 69/524 - (13%)

  Fly    24 SCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWND 88
            |.||.|::||...|:..||.|||||.|::..|.|.|.::|.||:|||||||:||||.||.|.|.|
Zfish    20 SLQGEHQRRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYD 84

  Fly    89 YNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKST 153
            |.|:||.:||.||.::|...:::||||:|:||||||.||.|:|||::|..:|:|.|:||||||||
Zfish    85 YYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKST 149

  Fly   154 CKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYA 218
            |.||:.|||||.|.|::|||||||.|..|||.:..   .|::.:|.||||.|:.:||::|...|.
Zfish   150 CYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQMID---ADITGYIANGEWDLVEVPGRRNERFYD 211

  Fly   219 CCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFL 283
            ||.|||.|:|||:.:|||||||..||::||||||::|||.|.||.|||||::||:|:|||||||:
Zfish   212 CCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFM 276

  Fly   284 NLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTV 348
            .||||.||.|||:||||                             ..||...|.:|..||:.||
Zfish   277 LLVAEIMPATSDSVPLI-----------------------------AQYFATTMVIVGLSVIATV 312

  Fly   349 VVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLL 413
            .||.||:...:..:||.|.:.|.|.|..|.|||.|||....|..           ...:..:|.|
Zfish   313 WVLQYHYHDPEGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPA-----------CHNKQPRSSL 366

  Fly   414 ANV-LDIDDDFRHTISGSQTAIG--------------SSASFGRPTTVEEHHTAI---------- 453
            ::| |:|......:.:|:...||              |.....|.....|....:
Zfish   367 SSVDLNISPGVAQSTNGNLLYIGFRGMDTIHYATSPDSGVICSRLVATGEEDVLLPGAQASSVSS 431

  Fly   454 -GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
             |....:|..||.|:::|:.|.|..|:|..:..:|||||.|:||.||:.|:||||:.|:.:|:||
Zfish   432 SGPGETELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSA 496

  Fly   518 PHII 521
            |:.:
Zfish   497 PNFV 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	229/518 (44%)
		LGIC_ECD_nAChR	55..236	CDD:349798	102/180 (57%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
chrna7a	NP_957513.1	LIC	3..496	CDD:455710	229/518 (44%)