DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and chrna7a

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_957513.1	Gene:	chrna7a / 394199	ZFINID:	ZDB-GENE-040108-3	Length:	509	Species:	Danio rerio

Alignment Length:	524	Identity:	232/524 - (44%)
Similarity:	312/524 - (59%)	Gaps:	69/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWND 88
            |.||.|::||...|:..||.|||||.|::..|.|.|.::|.||:|||||||:||||.||.|.|.|
Zfish    20 SLQGEHQRRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYD 84

  Fly    89 YNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKST 153
            |.|:||.:||.||.::|...:::||||:|:||||||.||.|:|||::|..:|:|.|:||||||||
Zfish    85 YYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKST 149

  Fly   154 CKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYA 218
            |.||:.|||||.|.|::|||||||.|..|||.:..   .|::.:|.||||.|:.:||::|...|.
Zfish   150 CYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQMID---ADITGYIANGEWDLVEVPGRRNERFYD 211

  Fly   219 CCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFL 283
            ||.|||.|:|||:.:|||||||..||::||||||::|||.|.||.|||||::||:|:|||||||:
Zfish   212 CCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFM 276

  Fly   284 NLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTV 348
            .||||.||.|||:||||                             ..||...|.:|..||:.||
Zfish   277 LLVAEIMPATSDSVPLI-----------------------------AQYFATTMVIVGLSVIATV 312

  Fly   349 VVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLL 413
            .||.||:...:..:||.|.:.|.|.|..|.|||.|||....|..           ...:..:|.|
Zfish   313 WVLQYHYHDPEGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPA-----------CHNKQPRSSL 366

  Fly   414 ANV-LDIDDDFRHTISGSQTAIG--------------SSASFGRPTTVEEHHTAI---------- 453
            ::| |:|......:.:|:...||              |.....|.....|....:
Zfish   367 SSVDLNISPGVAQSTNGNLLYIGFRGMDTIHYATSPDSGVICSRLVATGEEDVLLPGAQASSVSS 431

  Fly   454 -GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
             |....:|..||.|:::|:.|.|..|:|..:..:|||||.|:||.||:.|:||||:.|:.:|:||
Zfish   432 SGPGETELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSA 496

  Fly   518 PHII 521
            |:.:
Zfish   497 PNFV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	229/518 (44%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	102/180 (57%)
chrna7a	NP_957513.1	LIC	3..496	CDD:273305	229/518 (44%)
		Neur_chan_LBD	26..230	CDD:280998	114/206 (55%)
		Neur_chan_memb	237..492	CDD:280999	104/294 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980