Protein Alignment nAChRalpha6 and Rdl

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 402
• Identity: 88/402 - (21%)
• Similarity: 151/402 - (37%)
• Gaps: 112/402 - (27%)

  Fly     3 SPLPASLSLFV-LLIFLAIIKESCQGPHEK--------------------RLLNHLLSTYNTLER 46
            :|||.:..|.: |.|.:|:|.:  :..|::                    .:|:....:|:...|
  Fly    13 APLPRTPLLTIWLAINMALIAQ--ETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVR 75

  Fly    47 PVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITP--- 108
            |... ..|:||...:.:..|..:.|.....|.:.:....|.|..|.:.:..  ||:.|.:..
  Fly    76 PNYG-GPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRP--GVETLSVGSEFI 137

  Fly   109 NKLWKPDVLMYNSADEGFDGTYHTN--IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMK 171
            ..:|.||....|.....|.....:|  |.|.|:||..........::|.:::.:||.|.|.|.::
  Fly   138 KNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIE 202

  Fly   172 FGSWTY----------DGNQLDLV-LNSEDGGDLSDF-------------ITNGEWYLLAMPGKK 212
            ..|:.|          ||  |..| ::||  .:|..|             :|.|.:..||
  Fly   203 IESFGYTMRDIRYFWRDG--LSSVGMSSE--VELPQFRVLGHRQRATEINLTTGNYSRLA----- 258

  Fly   213 NTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD-SGEKLTLGVTIL 276
                   |         .||..|...||...:.:|..||..::.:.|.|..: :..::.||||.:
  Fly   259 -------C---------EIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTV 307

  Fly   277 LSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVA 341
            |::|..       |.:|:.|:|.|  :.:.|:.|:                 |||   |.:.:.|
  Fly   308 LTMTTL-------MSSTNAALPKI--SYVKSIDVY-----------------LGT---CFVMVFA 343

  Fly   342 SSVVLTVVVLNY 353
            |  :|....:.|
  Fly   344 S--LLEYATVGY 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	85/394 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	45/209 (22%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	45/209 (22%)
		Cys-loop	185..199	CDD:349809	5/13 (38%)
		Neur_chan_memb	274..588	CDD:460753	26/111 (23%)